Stress, glucocorticoid hormones, and hippocampal neural progenitor cells: Implications to mood disorders

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis and its end-effectors glucocorticoid hormones play central roles in the adaptive response to numerous stressors that can be either internal or external. Thus, this system has a strong impact on the brain hippocampus and its major functions, such as cognition, memory as well as behavior, and mood. The hippocampal area of the adult brain contains neural stem cells or more committed neural progenitor cells, which retain throughout the human life the ability of self-renewal and to differentiate into multiple neural cell lineages, such as neurons, astrocytes, and oligodendrocytes. Importantly, these characteristic cells contribute significantly to the above-indicated functions of the hippocampus, while various stressors and glucocorticoids influence proliferation, differentiation, and fate of these cells. This review offers an overview of the current understanding on the interactions between the HPA axis/glucocorticoid stress-responsive system and hippocampal neural progenitor cells by focusing on the actions of glucocorticoids. Also addressed is a further discussion on the implications of such interactions to the pathophysiology of mood disorders.

Original languageEnglish
Pages (from-to)230
Number of pages1
JournalFrontiers in Physiology
Volume6
Issue numberAug
DOIs
Publication statusPublished - 2015

Fingerprint

Mood Disorders
Glucocorticoids
Stem Cells
Hormones
Hippocampus
Aptitude
Neural Stem Cells
Oligodendroglia
Brain
Cell Lineage
Astrocytes
Cognition
Cell Differentiation
Neurons

Keywords

  • Dentate gyrus
  • Glucocorticoid receptor
  • Hippocampus
  • Major depression
  • Neural stem cells (NSCs)

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Stress, glucocorticoid hormones, and hippocampal neural progenitor cells : Implications to mood disorders. / Kino, Tomoshige.

In: Frontiers in Physiology, Vol. 6, No. Aug, 2015, p. 230.

Research output: Contribution to journalReview article

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