Abstract
Cellular proliferation and division are central processes in the development, survival and evolution of living systems. Transitioning into the cell division phase of the cell cycle encompasses dramatic remodeling of cellular organelles and signaling modules including Ca2+ signaling. As well, Ca2+ signals play important roles during progression through various stages of the cell cycle. A ubiquitous Ca2+ influx pathway that is activated based on intracellular Ca2+ store content is store-operated Ca2+ entry (SOCE). SOCE is activated through a complex interplay between a Ca2+ channel at the cell membrane, Orai1, and a Ca2+ sensor that localizes to the endoplasmic reticulum, STIM1. Herein, we discuss potential roles and regulation of STIM and Orai proteins during cellular proliferation.
| Original language | English |
|---|---|
| Pages (from-to) | 331-341 |
| Number of pages | 11 |
| Journal | Frontiers in Bioscience - Elite |
| Volume | 4 E |
| Issue number | 1 |
| Publication status | Published - 1 Jan 2012 |
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Keywords
- Cell division
- Cell Proliferation
- Orai
- Review
- STIM
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
STIM and Orai in cellular proliferation and division. / Courjaret, Raphael Jean; Machaca, Khaled.
In: Frontiers in Bioscience - Elite, Vol. 4 E, No. 1, 01.01.2012, p. 331-341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - STIM and Orai in cellular proliferation and division
AU - Courjaret, Raphael Jean
AU - Machaca, Khaled
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Cellular proliferation and division are central processes in the development, survival and evolution of living systems. Transitioning into the cell division phase of the cell cycle encompasses dramatic remodeling of cellular organelles and signaling modules including Ca2+ signaling. As well, Ca2+ signals play important roles during progression through various stages of the cell cycle. A ubiquitous Ca2+ influx pathway that is activated based on intracellular Ca2+ store content is store-operated Ca2+ entry (SOCE). SOCE is activated through a complex interplay between a Ca2+ channel at the cell membrane, Orai1, and a Ca2+ sensor that localizes to the endoplasmic reticulum, STIM1. Herein, we discuss potential roles and regulation of STIM and Orai proteins during cellular proliferation.
AB - Cellular proliferation and division are central processes in the development, survival and evolution of living systems. Transitioning into the cell division phase of the cell cycle encompasses dramatic remodeling of cellular organelles and signaling modules including Ca2+ signaling. As well, Ca2+ signals play important roles during progression through various stages of the cell cycle. A ubiquitous Ca2+ influx pathway that is activated based on intracellular Ca2+ store content is store-operated Ca2+ entry (SOCE). SOCE is activated through a complex interplay between a Ca2+ channel at the cell membrane, Orai1, and a Ca2+ sensor that localizes to the endoplasmic reticulum, STIM1. Herein, we discuss potential roles and regulation of STIM and Orai proteins during cellular proliferation.
KW - Cell division
KW - Cell Proliferation
KW - Orai
KW - Review
KW - STIM
UR - http://www.scopus.com/inward/record.url?scp=84860855086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860855086&partnerID=8YFLogxK
M3 - Article
VL - 4 E
SP - 331
EP - 341
JO - Frontiers in Bioscience - Elite
JF - Frontiers in Bioscience - Elite
SN - 1945-0494
IS - 1
ER -