Sr2+ can become incorporated into an agonist-sensitive, cytoplasmic Ca2+ store in a cell line derived from the equine sweat gland epithelium

W. H. Ko, J. D. Pediani, D. L. Bovell, S. M. Wilson

Research output: Contribution to journalArticle

5 Citations (Scopus)


We have explored the properties of a Ca2+-dependent cell-signalling pathway that becomes active when cultured equine sweat gland cells are stimulated with ATP. The ATP-regulated, Ca2+-influx pathway allowed Sr2+ to enter the cytoplasm but permitted only a minimal influx of Ba2+. Experiments in which cells were repeatedly stimulated with ATP suggested that Sr2+, but not Ba2+, could become incorporated into the agonist-sensitive, cytoplasmic Ca2+ store. Further evidence for this was provided by experiments using ionomycin, a Ca2+ ionophore which has no affinity for Sr2+.

Original languageEnglish
Pages (from-to)804-808
Number of pages5
Issue number8
Publication statusPublished - 1 Aug 1995



  • Ca mobilisation
  • Fura-2
  • epithelial cells
  • horse
  • ionomycin
  • nucleotide receptors
  • purinergic receptors
  • sweat gland

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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