Spectral phase-corrected GRAPPA reconstruction of three-dimensional echo-planar spectroscopic imaging (3D-EPSI)

Xiaoping Zhu, Andreas Ebel, Jim X. Ji, Norbert Schuff

Research output: Contribution to journalArticle

22 Citations (Scopus)


MR spectroscopic (MRS) images from a large volume of brain can be obtained using a 3D echo-planar spectroscopic imaging (3D-EPSI) sequence. However, routine applications of 3D-EPSI are still limited by a long scan time. In this communication, a new approach termed "spectral phase-corrected generalized autocalibrating partially parallel acquisitions" (SPC-GRAPPA) is introduced for the reconstruction of 3D-EPSI data to accelerate data acquisition while preserving the accuracy of quantitation of brain metabolites. In SPC-GRAPPA, voxel-by-voxel spectral phase alignment between metabolite 3D-EPSI from individual coil elements is performed in the frequency domain, utilizing the whole spectrum from interleaved water reference 3D-EPSI for robust estimation of the zero-order phase correction. The performance of SPC-GRAPPA was compared with that of fully encoded 3D-EPSI and conventional GRAPPA. Analysis of whole-brain 3D-EPSI data reconstructed by SPC-GRAPPA demonstrates that SPC-GRAPPA with an acceleration factor of 1.5 yields results very similar to those obtained by fully encoded 3D-EPSI, and is more accurate than conventional GRAPPA.

Original languageEnglish
Pages (from-to)815-820
Number of pages6
JournalMagnetic Resonance in Medicine
Issue number5
Publication statusPublished - 1 May 2007



  • Brain metabolites
  • Echoplanar spectroscopic imaging
  • Partial parallel imaging
  • Phase correction
  • Short echo time

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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