Soy protein improves cardiovascular risk in subclinical hypothyroidism: A randomized double-blinded crossover study

Thozhukat Sathyapalan, Zeeshan Javed, Alan S. Rigby, Eric S. Kilpatrick, Stephen L. Atkin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Soy protein with isoflavones appears to have an adverse effect on thyroid function, but it is not known whether it is the protein or isoflavone component that is deleterious. The effect of isoflavone-free soy on thyroid function was determined in patients with subclinical hypothyroidism, with a secondary aim of assessing its effect on cardiovascular risk indices. Methods: This was a randomized, double-blind, crossover study involving 80 patients with subclinical (compensated) hypothyroidism. Patients were randomly assigned to either isolated soy (isoflavone-free) protein (SP) or casein protein (CP) supplementation for 8 weeks, washed out for 8 weeks, and then crossed over for a further 8-week period. Results: Thyroid function was unaffected by either a SP or CP. There were significant decreases in fasting glucose (4.760.6 vs 5.561.4, P < 0.01), insulin resistance (3.3±3.0 vs 3.8±3.4, P = 0.05), total cholesterol (4.4 ± 0.9 vs 5.3 ± 1.2, P < 0.01), triglycerides (0.9 ± 0.5 vs 1.7 ± 0.9, P < 0.1), and highly sensitive C-reactive protein (hsCRP; 0.8 ± 0.7 vs 2.6 ± 2.8, P < 0.01) in the SP group compared with the CP group. Blood pressure, low-density lipoprotein, and high-density lipoprotein remained unchanged in both groups. Conclusion: SP alone had no effect on thyroid function in patients with subclinical hypothyroidism and resulted in a significant reduction in fasting glucose, insulin resistance, total cholesterol, triglycerides, and hsCRP compared with CP.

Original languageEnglish
Pages (from-to)423-430
Number of pages8
JournalJournal of the Endocrine Society
Volume1
Issue number5
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

Soybean Proteins
Hypothyroidism
Cross-Over Studies
Isoflavones
Caseins
Proteins
Thyroid Gland
Insulin Resistance
Fasting
Triglycerides
Cholesterol
Glucose
HDL Lipoproteins
LDL Lipoproteins
Double-Blind Method
C-Reactive Protein
Blood Pressure

Keywords

  • Cardiovascular risk
  • Isoflavone
  • Soy protein
  • Subclinical hypothyroidism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Soy protein improves cardiovascular risk in subclinical hypothyroidism : A randomized double-blinded crossover study. / Sathyapalan, Thozhukat; Javed, Zeeshan; Rigby, Alan S.; Kilpatrick, Eric S.; Atkin, Stephen L.

In: Journal of the Endocrine Society, Vol. 1, No. 5, 01.01.2017, p. 423-430.

Research output: Contribution to journalArticle

Sathyapalan, Thozhukat ; Javed, Zeeshan ; Rigby, Alan S. ; Kilpatrick, Eric S. ; Atkin, Stephen L. / Soy protein improves cardiovascular risk in subclinical hypothyroidism : A randomized double-blinded crossover study. In: Journal of the Endocrine Society. 2017 ; Vol. 1, No. 5. pp. 423-430.
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abstract = "Background: Soy protein with isoflavones appears to have an adverse effect on thyroid function, but it is not known whether it is the protein or isoflavone component that is deleterious. The effect of isoflavone-free soy on thyroid function was determined in patients with subclinical hypothyroidism, with a secondary aim of assessing its effect on cardiovascular risk indices. Methods: This was a randomized, double-blind, crossover study involving 80 patients with subclinical (compensated) hypothyroidism. Patients were randomly assigned to either isolated soy (isoflavone-free) protein (SP) or casein protein (CP) supplementation for 8 weeks, washed out for 8 weeks, and then crossed over for a further 8-week period. Results: Thyroid function was unaffected by either a SP or CP. There were significant decreases in fasting glucose (4.760.6 vs 5.561.4, P < 0.01), insulin resistance (3.3±3.0 vs 3.8±3.4, P = 0.05), total cholesterol (4.4 ± 0.9 vs 5.3 ± 1.2, P < 0.01), triglycerides (0.9 ± 0.5 vs 1.7 ± 0.9, P < 0.1), and highly sensitive C-reactive protein (hsCRP; 0.8 ± 0.7 vs 2.6 ± 2.8, P < 0.01) in the SP group compared with the CP group. Blood pressure, low-density lipoprotein, and high-density lipoprotein remained unchanged in both groups. Conclusion: SP alone had no effect on thyroid function in patients with subclinical hypothyroidism and resulted in a significant reduction in fasting glucose, insulin resistance, total cholesterol, triglycerides, and hsCRP compared with CP.",
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