Sox2: A Regulatory Factor in Tumorigenesis and Metastasis

Sameer Chaudhary, Zeyaul Islam, Vijaya Mishra, Sakshi Rawat, Ghulam Md Ashraf, Prasanna Kolatkar

Research output: Contribution to journalArticle

Abstract

The transcription factor Sox2 plays an important role in various phases of embryonic development, including cell fate and differentiation. These key regulatory functions are facilitated by binding to specific DNA sequences in combination with partner proteins to exert their effects. Recently, overexpression and gene amplification of Sox2 has been associated with tumor aggression and metastasis in various cancer types, including breast, prostate, lung, ovarian and colon cancer. All the different roles for Sox2 involve complicated regulatory networks consisting of protein-protein and protein-nucleic acid interactions. Their involvement in the EMT modulation is possibly enabled by Wnt/ β-catenin and other signaling pathways. There are number of in vivo models which show Sox2 association with increased cancer aggressiveness, resistance to chemo-radiation therapy and decreased survival rate suggesting Sox2 as a therapeutic target. This review will focus on the different roles for Sox2 in metastasis and tumorigenesis. We will also review the mechanism of action underlying the cooperative Sox2- DNA/partner factors binding where Sox2 can be potentially explored for a therapeutic opportunity to treat cancers.

Original languageEnglish
Pages (from-to)495-504
Number of pages10
JournalCurrent protein & peptide science
Volume20
Issue number6
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Carcinogenesis
Neoplasm Metastasis
Proteins
Breast Neoplasms
Catenins
Neoplasms
Gene Amplification
DNA sequences
Radiotherapy
Aggression
Ovarian Neoplasms
Colonic Neoplasms
Nucleic Acids
Embryonic Development
Tumors
Cell Differentiation
Lung Neoplasms
Prostatic Neoplasms
Transcription Factors
Modulation

Keywords

  • endodermal-mesenchymal transition
  • HMG domain
  • metastasis
  • overexpression
  • transcription factor
  • tumor propagation.
  • Wnt/β-catonin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Sox2 : A Regulatory Factor in Tumorigenesis and Metastasis. / Chaudhary, Sameer; Islam, Zeyaul; Mishra, Vijaya; Rawat, Sakshi; Ashraf, Ghulam Md; Kolatkar, Prasanna.

In: Current protein & peptide science, Vol. 20, No. 6, 01.01.2019, p. 495-504.

Research output: Contribution to journalArticle

Chaudhary, Sameer ; Islam, Zeyaul ; Mishra, Vijaya ; Rawat, Sakshi ; Ashraf, Ghulam Md ; Kolatkar, Prasanna. / Sox2 : A Regulatory Factor in Tumorigenesis and Metastasis. In: Current protein & peptide science. 2019 ; Vol. 20, No. 6. pp. 495-504.
@article{d4b91fdee3304c5c956492c5fd68fdd8,
title = "Sox2: A Regulatory Factor in Tumorigenesis and Metastasis",
abstract = "The transcription factor Sox2 plays an important role in various phases of embryonic development, including cell fate and differentiation. These key regulatory functions are facilitated by binding to specific DNA sequences in combination with partner proteins to exert their effects. Recently, overexpression and gene amplification of Sox2 has been associated with tumor aggression and metastasis in various cancer types, including breast, prostate, lung, ovarian and colon cancer. All the different roles for Sox2 involve complicated regulatory networks consisting of protein-protein and protein-nucleic acid interactions. Their involvement in the EMT modulation is possibly enabled by Wnt/ β-catenin and other signaling pathways. There are number of in vivo models which show Sox2 association with increased cancer aggressiveness, resistance to chemo-radiation therapy and decreased survival rate suggesting Sox2 as a therapeutic target. This review will focus on the different roles for Sox2 in metastasis and tumorigenesis. We will also review the mechanism of action underlying the cooperative Sox2- DNA/partner factors binding where Sox2 can be potentially explored for a therapeutic opportunity to treat cancers.",
keywords = "endodermal-mesenchymal transition, HMG domain, metastasis, overexpression, transcription factor, tumor propagation., Wnt/β-catonin",
author = "Sameer Chaudhary and Zeyaul Islam and Vijaya Mishra and Sakshi Rawat and Ashraf, {Ghulam Md} and Prasanna Kolatkar",
year = "2019",
month = "1",
day = "1",
doi = "10.2174/1389203720666190325102255",
language = "English",
volume = "20",
pages = "495--504",
journal = "Current Protein and Peptide Science",
issn = "1389-2037",
publisher = "Bentham Science Publishers B.V.",
number = "6",

}

TY - JOUR

T1 - Sox2

T2 - A Regulatory Factor in Tumorigenesis and Metastasis

AU - Chaudhary, Sameer

AU - Islam, Zeyaul

AU - Mishra, Vijaya

AU - Rawat, Sakshi

AU - Ashraf, Ghulam Md

AU - Kolatkar, Prasanna

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The transcription factor Sox2 plays an important role in various phases of embryonic development, including cell fate and differentiation. These key regulatory functions are facilitated by binding to specific DNA sequences in combination with partner proteins to exert their effects. Recently, overexpression and gene amplification of Sox2 has been associated with tumor aggression and metastasis in various cancer types, including breast, prostate, lung, ovarian and colon cancer. All the different roles for Sox2 involve complicated regulatory networks consisting of protein-protein and protein-nucleic acid interactions. Their involvement in the EMT modulation is possibly enabled by Wnt/ β-catenin and other signaling pathways. There are number of in vivo models which show Sox2 association with increased cancer aggressiveness, resistance to chemo-radiation therapy and decreased survival rate suggesting Sox2 as a therapeutic target. This review will focus on the different roles for Sox2 in metastasis and tumorigenesis. We will also review the mechanism of action underlying the cooperative Sox2- DNA/partner factors binding where Sox2 can be potentially explored for a therapeutic opportunity to treat cancers.

AB - The transcription factor Sox2 plays an important role in various phases of embryonic development, including cell fate and differentiation. These key regulatory functions are facilitated by binding to specific DNA sequences in combination with partner proteins to exert their effects. Recently, overexpression and gene amplification of Sox2 has been associated with tumor aggression and metastasis in various cancer types, including breast, prostate, lung, ovarian and colon cancer. All the different roles for Sox2 involve complicated regulatory networks consisting of protein-protein and protein-nucleic acid interactions. Their involvement in the EMT modulation is possibly enabled by Wnt/ β-catenin and other signaling pathways. There are number of in vivo models which show Sox2 association with increased cancer aggressiveness, resistance to chemo-radiation therapy and decreased survival rate suggesting Sox2 as a therapeutic target. This review will focus on the different roles for Sox2 in metastasis and tumorigenesis. We will also review the mechanism of action underlying the cooperative Sox2- DNA/partner factors binding where Sox2 can be potentially explored for a therapeutic opportunity to treat cancers.

KW - endodermal-mesenchymal transition

KW - HMG domain

KW - metastasis

KW - overexpression

KW - transcription factor

KW - tumor propagation.

KW - Wnt/β-catonin

UR - http://www.scopus.com/inward/record.url?scp=85067267043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067267043&partnerID=8YFLogxK

U2 - 10.2174/1389203720666190325102255

DO - 10.2174/1389203720666190325102255

M3 - Article

C2 - 30907312

AN - SCOPUS:85067267043

VL - 20

SP - 495

EP - 504

JO - Current Protein and Peptide Science

JF - Current Protein and Peptide Science

SN - 1389-2037

IS - 6

ER -