Sources of HIV incidence among stable couples in sub-Saharan Africa

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Introduction: The recent availability of efficacious prevention interventions among stable couples offers new opportunities for reducing HIV incidence in sub-Saharan Africa. Understanding the dynamics of HIV incidence among stable couples is critical to inform HIV prevention strategy across sub-Saharan Africa. Methods: We quantified the sources of HIV incidence arising among stable couples in sub-Saharan Africa using a cohort-type mathematical model parameterized by nationally representative data. Uncertainty and sensitivity analyses were incorporated. Results: HIV incidence arising among stable concordant HIV-negative couples contribute each year, on average, 29.4% of total HIV incidence; of those, 22.5% (range: 11.1%-39.8%) are infections acquired by one of the partners from sources external to the couple, less than 1% are infections acquired by both partners from external sources within a year and 6.8% (range: 3.6%-11.6%) are transmissions to the uninfected partner in the couple in less than a year after the other partner acquired the infection from an external source. The mean contribution of stable HIV sero-discordant couples to total HIV incidence is 30.4%, with most of those, 29.7% (range: 9.1%-47.9%), being due to HIV transmissions from the infected to the uninfected partner within the couple. The remaining incidence, 40.2% (range: 23.7%-64.6%), occurs among persons not in stable couples. Conclusions: Close to two-thirds of total HIV incidence in sub-Saharan Africa occur among stable couples; however, only half of this incidence is attributed to HIV transmissions from the infected to the uninfected partner in the couple. The remaining incidence is acquired through extra-partner sex. Substantial reductions in HIV incidence can be achieved only through a prevention approach that targets all modes of HIV exposure among stable couples and among individuals not in stable couples.

Original languageEnglish
Article number18765
JournalJournal of the International AIDS Society
Volume17
DOIs
Publication statusPublished - 21 Feb 2014

Fingerprint

Africa South of the Sahara
HIV
Incidence
Infection
Uncertainty

Keywords

  • Demographic and health surveys
  • HIV incidence
  • Mathematical model
  • Sources of infection
  • Stable couples
  • Sub-Saharan Africa

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Sources of HIV incidence among stable couples in sub-Saharan Africa. / Chemaitelly, Hiam; Awad, Susanne; Shelton, James D.; Aburaddad, Laith.

In: Journal of the International AIDS Society, Vol. 17, 18765, 21.02.2014.

Research output: Contribution to journalArticle

@article{3ff72ee6c4e04b2281b71464a75325df,
title = "Sources of HIV incidence among stable couples in sub-Saharan Africa",
abstract = "Introduction: The recent availability of efficacious prevention interventions among stable couples offers new opportunities for reducing HIV incidence in sub-Saharan Africa. Understanding the dynamics of HIV incidence among stable couples is critical to inform HIV prevention strategy across sub-Saharan Africa. Methods: We quantified the sources of HIV incidence arising among stable couples in sub-Saharan Africa using a cohort-type mathematical model parameterized by nationally representative data. Uncertainty and sensitivity analyses were incorporated. Results: HIV incidence arising among stable concordant HIV-negative couples contribute each year, on average, 29.4{\%} of total HIV incidence; of those, 22.5{\%} (range: 11.1{\%}-39.8{\%}) are infections acquired by one of the partners from sources external to the couple, less than 1{\%} are infections acquired by both partners from external sources within a year and 6.8{\%} (range: 3.6{\%}-11.6{\%}) are transmissions to the uninfected partner in the couple in less than a year after the other partner acquired the infection from an external source. The mean contribution of stable HIV sero-discordant couples to total HIV incidence is 30.4{\%}, with most of those, 29.7{\%} (range: 9.1{\%}-47.9{\%}), being due to HIV transmissions from the infected to the uninfected partner within the couple. The remaining incidence, 40.2{\%} (range: 23.7{\%}-64.6{\%}), occurs among persons not in stable couples. Conclusions: Close to two-thirds of total HIV incidence in sub-Saharan Africa occur among stable couples; however, only half of this incidence is attributed to HIV transmissions from the infected to the uninfected partner in the couple. The remaining incidence is acquired through extra-partner sex. Substantial reductions in HIV incidence can be achieved only through a prevention approach that targets all modes of HIV exposure among stable couples and among individuals not in stable couples.",
keywords = "Demographic and health surveys, HIV incidence, Mathematical model, Sources of infection, Stable couples, Sub-Saharan Africa",
author = "Hiam Chemaitelly and Susanne Awad and Shelton, {James D.} and Laith Aburaddad",
year = "2014",
month = "2",
day = "21",
doi = "10.7448/IAS.17.1.18765",
language = "English",
volume = "17",
journal = "Journal of the International AIDS Society",
issn = "1758-2652",
publisher = "International AIDS Society",

}

TY - JOUR

T1 - Sources of HIV incidence among stable couples in sub-Saharan Africa

AU - Chemaitelly, Hiam

AU - Awad, Susanne

AU - Shelton, James D.

AU - Aburaddad, Laith

PY - 2014/2/21

Y1 - 2014/2/21

N2 - Introduction: The recent availability of efficacious prevention interventions among stable couples offers new opportunities for reducing HIV incidence in sub-Saharan Africa. Understanding the dynamics of HIV incidence among stable couples is critical to inform HIV prevention strategy across sub-Saharan Africa. Methods: We quantified the sources of HIV incidence arising among stable couples in sub-Saharan Africa using a cohort-type mathematical model parameterized by nationally representative data. Uncertainty and sensitivity analyses were incorporated. Results: HIV incidence arising among stable concordant HIV-negative couples contribute each year, on average, 29.4% of total HIV incidence; of those, 22.5% (range: 11.1%-39.8%) are infections acquired by one of the partners from sources external to the couple, less than 1% are infections acquired by both partners from external sources within a year and 6.8% (range: 3.6%-11.6%) are transmissions to the uninfected partner in the couple in less than a year after the other partner acquired the infection from an external source. The mean contribution of stable HIV sero-discordant couples to total HIV incidence is 30.4%, with most of those, 29.7% (range: 9.1%-47.9%), being due to HIV transmissions from the infected to the uninfected partner within the couple. The remaining incidence, 40.2% (range: 23.7%-64.6%), occurs among persons not in stable couples. Conclusions: Close to two-thirds of total HIV incidence in sub-Saharan Africa occur among stable couples; however, only half of this incidence is attributed to HIV transmissions from the infected to the uninfected partner in the couple. The remaining incidence is acquired through extra-partner sex. Substantial reductions in HIV incidence can be achieved only through a prevention approach that targets all modes of HIV exposure among stable couples and among individuals not in stable couples.

AB - Introduction: The recent availability of efficacious prevention interventions among stable couples offers new opportunities for reducing HIV incidence in sub-Saharan Africa. Understanding the dynamics of HIV incidence among stable couples is critical to inform HIV prevention strategy across sub-Saharan Africa. Methods: We quantified the sources of HIV incidence arising among stable couples in sub-Saharan Africa using a cohort-type mathematical model parameterized by nationally representative data. Uncertainty and sensitivity analyses were incorporated. Results: HIV incidence arising among stable concordant HIV-negative couples contribute each year, on average, 29.4% of total HIV incidence; of those, 22.5% (range: 11.1%-39.8%) are infections acquired by one of the partners from sources external to the couple, less than 1% are infections acquired by both partners from external sources within a year and 6.8% (range: 3.6%-11.6%) are transmissions to the uninfected partner in the couple in less than a year after the other partner acquired the infection from an external source. The mean contribution of stable HIV sero-discordant couples to total HIV incidence is 30.4%, with most of those, 29.7% (range: 9.1%-47.9%), being due to HIV transmissions from the infected to the uninfected partner within the couple. The remaining incidence, 40.2% (range: 23.7%-64.6%), occurs among persons not in stable couples. Conclusions: Close to two-thirds of total HIV incidence in sub-Saharan Africa occur among stable couples; however, only half of this incidence is attributed to HIV transmissions from the infected to the uninfected partner in the couple. The remaining incidence is acquired through extra-partner sex. Substantial reductions in HIV incidence can be achieved only through a prevention approach that targets all modes of HIV exposure among stable couples and among individuals not in stable couples.

KW - Demographic and health surveys

KW - HIV incidence

KW - Mathematical model

KW - Sources of infection

KW - Stable couples

KW - Sub-Saharan Africa

UR - http://www.scopus.com/inward/record.url?scp=84896884960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896884960&partnerID=8YFLogxK

U2 - 10.7448/IAS.17.1.18765

DO - 10.7448/IAS.17.1.18765

M3 - Article

VL - 17

JO - Journal of the International AIDS Society

JF - Journal of the International AIDS Society

SN - 1758-2652

M1 - 18765

ER -