Abstract
Somatostatins are neuropeptides that have a downregulatory effect on various physiological processes. Their use in the management of certain endocrine tumours is well recognized. Their use in thyroid cancer is not established, although there is some evidence to suggest that they have a role in advanced metastatic disease. We report a case of a patient with advanced metastatic follicular thyroid cancer which demonstrated strong octreotide uptake with reduced avidity for I131. Treatment with the somatostatin analogue octreotide, however, failed to achieve a significant response. We feel this case is important as it suggests that although octreotide provides a useful further imaging modality in differentiated thyroid cancer, it has no therapeutic role.
| Original language | English |
|---|---|
| Pages (from-to) | 653-654 |
| Number of pages | 2 |
| Journal | Journal of Laryngology and Otology |
| Volume | 118 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2004 |
| Externally published | Yes |
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Keywords
- Somatostatin
- Thyroid Neoplasms
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Somatostatin analogues have no role in the treatment of advanced differentiated thyroid cancer. / Alhamarneh, O.; Murphy, J.; Atkin, Stephen; England, R. J A.
In: Journal of Laryngology and Otology, Vol. 118, No. 8, 08.2004, p. 653-654.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Somatostatin analogues have no role in the treatment of advanced differentiated thyroid cancer
AU - Alhamarneh, O.
AU - Murphy, J.
AU - Atkin, Stephen
AU - England, R. J A
PY - 2004/8
Y1 - 2004/8
N2 - Somatostatins are neuropeptides that have a downregulatory effect on various physiological processes. Their use in the management of certain endocrine tumours is well recognized. Their use in thyroid cancer is not established, although there is some evidence to suggest that they have a role in advanced metastatic disease. We report a case of a patient with advanced metastatic follicular thyroid cancer which demonstrated strong octreotide uptake with reduced avidity for I131. Treatment with the somatostatin analogue octreotide, however, failed to achieve a significant response. We feel this case is important as it suggests that although octreotide provides a useful further imaging modality in differentiated thyroid cancer, it has no therapeutic role.
AB - Somatostatins are neuropeptides that have a downregulatory effect on various physiological processes. Their use in the management of certain endocrine tumours is well recognized. Their use in thyroid cancer is not established, although there is some evidence to suggest that they have a role in advanced metastatic disease. We report a case of a patient with advanced metastatic follicular thyroid cancer which demonstrated strong octreotide uptake with reduced avidity for I131. Treatment with the somatostatin analogue octreotide, however, failed to achieve a significant response. We feel this case is important as it suggests that although octreotide provides a useful further imaging modality in differentiated thyroid cancer, it has no therapeutic role.
KW - Somatostatin
KW - Thyroid Neoplasms
UR - http://www.scopus.com/inward/record.url?scp=4644332284&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4644332284&partnerID=8YFLogxK
U2 - 10.1258/0022215041917853
DO - 10.1258/0022215041917853
M3 - Article
C2 - 15453947
AN - SCOPUS:4644332284
VL - 118
SP - 653
EP - 654
JO - Journal of Laryngology and Otology
JF - Journal of Laryngology and Otology
SN - 0022-2151
IS - 8
ER -