SNP in the 5′ region of the NTRK3 gene is associated with panic disorder

Lluís Armengol, Mònica Gratacòs, Gustave Pérez, Antoni Bulbena, Rocio Martín-Santos, Xavier P. Estivill

Research output: Contribution to journalArticle

Abstract

A neuroanatomical hypothesis has been proposed for several psychi.atric disorders, by which the alteration of the neuronal composition and plasticity would be underlying such disorders. An abnormal firing rate in the noradrenergic neurons of the locus coeruleus has been found during panic attacks. Since NTRK3 is the only receptor for neurotrophin-3 in the locus coeruleus, being a good candidate gene for panic disorder. A sample of 59 consecutive outpatients (both sexes and older than 18), diagnosed of panic disorder with or without agoraphobia (SCID-DSM-III-R), was obtained from an Anxiety Unit at the Hospital del Mar. All subjects gave written informed consent to participate in the study. Control samples consisted of 86 adult sex-matched unrelated individuals for whom anxiety disorders was not assessed. PCR-SSCP analysis of the 5′ region and exons plus the intron/exon boundaries of the NTRK3 gene was carried out and four SNPs were identified. A significant association (X2 = 5.73, P = 0.017) between a SNP in the 5′ region of NTRK3 and panic disorder was detected. The association between the 5′ region SNP in the NTRK3 gene gives further support for a neuroanatomical hypothesis of panic disorders. Functional studies of this SNP and other variants within NTRK3 should provide a physiological basis for this association. Replication in other populations should further define a role of NTRK3 in panic disorder.

Original languageEnglish
Pages (from-to)578
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume105
Issue number7
Publication statusPublished - 8 Oct 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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