Small fibre pathology is associated with erectile dysfunction in men with type 2 diabetes

Shaishav Dhage, Jan Hoong Ho, Maryam Ferdousi, Alise Kalteniece, Shazli Azmi, Safwaan Adam, Andrew Marshall, Maria Jeziorska, Rachelle Donn, Handrean Soran, Rayaz A. Malik

Research output: Contribution to journalArticle

Abstract

Aims: The aim of this study was to evaluate the contribution of small and large fibre neuropathy to erectile dysfunction (ED) in men with type 2 diabetes (T2D). Methods: Measures of small and large fibre neuropathy were evaluated in 49 participants with T2D and 20 age-matched controls. Results: ED was present in 59% of participants with T2D. There was no difference in age, duration of diabetes, blood pressure, lipid profile, vibration perception threshold (V) (14.3 ± 7.8 vs 11.2 ± 6.6, P =.429), peroneal (41.4 ± 8.2 vs 44.8 ± 4.4, P =.10) and sural (45.4 ± 5.6 vs 47.1 ± 5.8) nerve conduction velocities (m/s), cold (25.1 ± 3.8 vs 26.2 ± 2.9, P =.815) and warm (43.2 ± 4.0 vs 41.0 ± 3.8) perception thresholds (°C), and deep breathing heart rate variability (18 ± 8 vs 18 ± 8) between participants with and without ED. However, intraepidermal nerve fibre density (no./mm2) (4.6 ± 2.8 vs 13.7 ± 2.7, P <.001), corneal nerve fibre density (no./mm2) (23.5 ± 6.8 vs 31.3 ± 8.2, P <.001), corneal nerve fibre branch density (no./mm2) (55.4 ± 35.3 vs 97.7 ± 46.4, P =.004), corneal nerve fibre length (mm/mm2) (17.6 ± 6.8 vs 27.3 ± 6.8, P <.001), and sural (7.7 ± 6.1 vs 14.6 ± 6.7, P =.003) and peroneal (2.5 ± 2.0 vs 4.7 ± 2.0, P =.003) nerve amplitudes were significantly lower in participants with ED compared with those without ED. Conclusion: ED affects almost 2/3 of men with T2D and is associated with small nerve fibre damage but preserved nerve conduction and cardiac autonomic function. Corneal confocal microscopy may serve as a useful non-invasive imaging method to identify small fibre damage in patients with T2D and ED.

Original languageEnglish
Article numbere3263
JournalDiabetes/Metabolism Research and Reviews
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Fingerprint

Erectile Dysfunction
Type 2 Diabetes Mellitus
Nerve Fibers
Pathology
Neural Conduction
Vibration
Confocal Microscopy
Respiration
Heart Rate
Blood Pressure
Lipids

Keywords

  • corneal confocal microscopy
  • erectile dysfunction
  • neuropathy
  • small fibre neuropathy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Small fibre pathology is associated with erectile dysfunction in men with type 2 diabetes. / Dhage, Shaishav; Ho, Jan Hoong; Ferdousi, Maryam; Kalteniece, Alise; Azmi, Shazli; Adam, Safwaan; Marshall, Andrew; Jeziorska, Maria; Donn, Rachelle; Soran, Handrean; Malik, Rayaz A.

In: Diabetes/Metabolism Research and Reviews, 01.01.2019.

Research output: Contribution to journalArticle

Dhage, S, Ho, JH, Ferdousi, M, Kalteniece, A, Azmi, S, Adam, S, Marshall, A, Jeziorska, M, Donn, R, Soran, H & Malik, RA 2019, 'Small fibre pathology is associated with erectile dysfunction in men with type 2 diabetes', Diabetes/Metabolism Research and Reviews. https://doi.org/10.1002/dmrr.3263
Dhage, Shaishav ; Ho, Jan Hoong ; Ferdousi, Maryam ; Kalteniece, Alise ; Azmi, Shazli ; Adam, Safwaan ; Marshall, Andrew ; Jeziorska, Maria ; Donn, Rachelle ; Soran, Handrean ; Malik, Rayaz A. / Small fibre pathology is associated with erectile dysfunction in men with type 2 diabetes. In: Diabetes/Metabolism Research and Reviews. 2019.
@article{68b0b7d490fa4521b313d539714f4375,
title = "Small fibre pathology is associated with erectile dysfunction in men with type 2 diabetes",
abstract = "Aims: The aim of this study was to evaluate the contribution of small and large fibre neuropathy to erectile dysfunction (ED) in men with type 2 diabetes (T2D). Methods: Measures of small and large fibre neuropathy were evaluated in 49 participants with T2D and 20 age-matched controls. Results: ED was present in 59{\%} of participants with T2D. There was no difference in age, duration of diabetes, blood pressure, lipid profile, vibration perception threshold (V) (14.3 ± 7.8 vs 11.2 ± 6.6, P =.429), peroneal (41.4 ± 8.2 vs 44.8 ± 4.4, P =.10) and sural (45.4 ± 5.6 vs 47.1 ± 5.8) nerve conduction velocities (m/s), cold (25.1 ± 3.8 vs 26.2 ± 2.9, P =.815) and warm (43.2 ± 4.0 vs 41.0 ± 3.8) perception thresholds (°C), and deep breathing heart rate variability (18 ± 8 vs 18 ± 8) between participants with and without ED. However, intraepidermal nerve fibre density (no./mm2) (4.6 ± 2.8 vs 13.7 ± 2.7, P <.001), corneal nerve fibre density (no./mm2) (23.5 ± 6.8 vs 31.3 ± 8.2, P <.001), corneal nerve fibre branch density (no./mm2) (55.4 ± 35.3 vs 97.7 ± 46.4, P =.004), corneal nerve fibre length (mm/mm2) (17.6 ± 6.8 vs 27.3 ± 6.8, P <.001), and sural (7.7 ± 6.1 vs 14.6 ± 6.7, P =.003) and peroneal (2.5 ± 2.0 vs 4.7 ± 2.0, P =.003) nerve amplitudes were significantly lower in participants with ED compared with those without ED. Conclusion: ED affects almost 2/3 of men with T2D and is associated with small nerve fibre damage but preserved nerve conduction and cardiac autonomic function. Corneal confocal microscopy may serve as a useful non-invasive imaging method to identify small fibre damage in patients with T2D and ED.",
keywords = "corneal confocal microscopy, erectile dysfunction, neuropathy, small fibre neuropathy",
author = "Shaishav Dhage and Ho, {Jan Hoong} and Maryam Ferdousi and Alise Kalteniece and Shazli Azmi and Safwaan Adam and Andrew Marshall and Maria Jeziorska and Rachelle Donn and Handrean Soran and Malik, {Rayaz A.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/dmrr.3263",
language = "English",
journal = "Diabetes/Metabolism Research and Reviews",
issn = "1520-7552",
publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - Small fibre pathology is associated with erectile dysfunction in men with type 2 diabetes

AU - Dhage, Shaishav

AU - Ho, Jan Hoong

AU - Ferdousi, Maryam

AU - Kalteniece, Alise

AU - Azmi, Shazli

AU - Adam, Safwaan

AU - Marshall, Andrew

AU - Jeziorska, Maria

AU - Donn, Rachelle

AU - Soran, Handrean

AU - Malik, Rayaz A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aims: The aim of this study was to evaluate the contribution of small and large fibre neuropathy to erectile dysfunction (ED) in men with type 2 diabetes (T2D). Methods: Measures of small and large fibre neuropathy were evaluated in 49 participants with T2D and 20 age-matched controls. Results: ED was present in 59% of participants with T2D. There was no difference in age, duration of diabetes, blood pressure, lipid profile, vibration perception threshold (V) (14.3 ± 7.8 vs 11.2 ± 6.6, P =.429), peroneal (41.4 ± 8.2 vs 44.8 ± 4.4, P =.10) and sural (45.4 ± 5.6 vs 47.1 ± 5.8) nerve conduction velocities (m/s), cold (25.1 ± 3.8 vs 26.2 ± 2.9, P =.815) and warm (43.2 ± 4.0 vs 41.0 ± 3.8) perception thresholds (°C), and deep breathing heart rate variability (18 ± 8 vs 18 ± 8) between participants with and without ED. However, intraepidermal nerve fibre density (no./mm2) (4.6 ± 2.8 vs 13.7 ± 2.7, P <.001), corneal nerve fibre density (no./mm2) (23.5 ± 6.8 vs 31.3 ± 8.2, P <.001), corneal nerve fibre branch density (no./mm2) (55.4 ± 35.3 vs 97.7 ± 46.4, P =.004), corneal nerve fibre length (mm/mm2) (17.6 ± 6.8 vs 27.3 ± 6.8, P <.001), and sural (7.7 ± 6.1 vs 14.6 ± 6.7, P =.003) and peroneal (2.5 ± 2.0 vs 4.7 ± 2.0, P =.003) nerve amplitudes were significantly lower in participants with ED compared with those without ED. Conclusion: ED affects almost 2/3 of men with T2D and is associated with small nerve fibre damage but preserved nerve conduction and cardiac autonomic function. Corneal confocal microscopy may serve as a useful non-invasive imaging method to identify small fibre damage in patients with T2D and ED.

AB - Aims: The aim of this study was to evaluate the contribution of small and large fibre neuropathy to erectile dysfunction (ED) in men with type 2 diabetes (T2D). Methods: Measures of small and large fibre neuropathy were evaluated in 49 participants with T2D and 20 age-matched controls. Results: ED was present in 59% of participants with T2D. There was no difference in age, duration of diabetes, blood pressure, lipid profile, vibration perception threshold (V) (14.3 ± 7.8 vs 11.2 ± 6.6, P =.429), peroneal (41.4 ± 8.2 vs 44.8 ± 4.4, P =.10) and sural (45.4 ± 5.6 vs 47.1 ± 5.8) nerve conduction velocities (m/s), cold (25.1 ± 3.8 vs 26.2 ± 2.9, P =.815) and warm (43.2 ± 4.0 vs 41.0 ± 3.8) perception thresholds (°C), and deep breathing heart rate variability (18 ± 8 vs 18 ± 8) between participants with and without ED. However, intraepidermal nerve fibre density (no./mm2) (4.6 ± 2.8 vs 13.7 ± 2.7, P <.001), corneal nerve fibre density (no./mm2) (23.5 ± 6.8 vs 31.3 ± 8.2, P <.001), corneal nerve fibre branch density (no./mm2) (55.4 ± 35.3 vs 97.7 ± 46.4, P =.004), corneal nerve fibre length (mm/mm2) (17.6 ± 6.8 vs 27.3 ± 6.8, P <.001), and sural (7.7 ± 6.1 vs 14.6 ± 6.7, P =.003) and peroneal (2.5 ± 2.0 vs 4.7 ± 2.0, P =.003) nerve amplitudes were significantly lower in participants with ED compared with those without ED. Conclusion: ED affects almost 2/3 of men with T2D and is associated with small nerve fibre damage but preserved nerve conduction and cardiac autonomic function. Corneal confocal microscopy may serve as a useful non-invasive imaging method to identify small fibre damage in patients with T2D and ED.

KW - corneal confocal microscopy

KW - erectile dysfunction

KW - neuropathy

KW - small fibre neuropathy

UR - http://www.scopus.com/inward/record.url?scp=85076765256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076765256&partnerID=8YFLogxK

U2 - 10.1002/dmrr.3263

DO - 10.1002/dmrr.3263

M3 - Article

C2 - 31833632

AN - SCOPUS:85076765256

JO - Diabetes/Metabolism Research and Reviews

JF - Diabetes/Metabolism Research and Reviews

SN - 1520-7552

M1 - e3263

ER -