Small bowel and liver/small bowel transplantation in children.

J. Reyes, A. G. Tzakis, S. Todo, Bakr Nour, T. E. Starzl

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

A clinical trial of intestinal transplantation was initiated at the University of Pittsburgh in May 1990. Eleven children received either a combined liver/small bowel graft (n = 8) or an isolated small bowel graft (n = 3). Induction as well as maintenance immunosuppression was with FK-506 and steroids. Four patients were male, and seven were female; the age range was 6 months to 10.2 years. There were 3 deaths (all in recipients of the combined liver/small bowel graft), which were attributed to graft-versus-host disease (n = 1), posttransplant lymphoproliferative disease (n = 1), and biliary leak (n = 1). Transplantation of the intestine has evolved into a feasible operation, with an overall patient and graft survival rate of 73%. These survivors are free of total parenteral nutrition, and the majority are home. These encouraging results justify further clinical trials.

Original languageEnglish
Pages (from-to)289-300
Number of pages12
JournalSeminars in Pediatric Surgery
Volume2
Issue number4
Publication statusPublished - Nov 1993
Externally publishedYes

Fingerprint

Transplantation
Transplants
Home Total Parenteral Nutrition
Liver
Clinical Trials
Tacrolimus
Graft vs Host Disease
Graft Survival
Immunosuppression
Intestines
Survivors
Survival Rate
Steroids
Maintenance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Reyes, J., Tzakis, A. G., Todo, S., Nour, B., & Starzl, T. E. (1993). Small bowel and liver/small bowel transplantation in children. Seminars in Pediatric Surgery, 2(4), 289-300.

Small bowel and liver/small bowel transplantation in children. / Reyes, J.; Tzakis, A. G.; Todo, S.; Nour, Bakr; Starzl, T. E.

In: Seminars in Pediatric Surgery, Vol. 2, No. 4, 11.1993, p. 289-300.

Research output: Contribution to journalReview article

Reyes, J, Tzakis, AG, Todo, S, Nour, B & Starzl, TE 1993, 'Small bowel and liver/small bowel transplantation in children.', Seminars in Pediatric Surgery, vol. 2, no. 4, pp. 289-300.
Reyes, J. ; Tzakis, A. G. ; Todo, S. ; Nour, Bakr ; Starzl, T. E. / Small bowel and liver/small bowel transplantation in children. In: Seminars in Pediatric Surgery. 1993 ; Vol. 2, No. 4. pp. 289-300.
@article{d5687b60a0e047d3937bc5b441c7f196,
title = "Small bowel and liver/small bowel transplantation in children.",
abstract = "A clinical trial of intestinal transplantation was initiated at the University of Pittsburgh in May 1990. Eleven children received either a combined liver/small bowel graft (n = 8) or an isolated small bowel graft (n = 3). Induction as well as maintenance immunosuppression was with FK-506 and steroids. Four patients were male, and seven were female; the age range was 6 months to 10.2 years. There were 3 deaths (all in recipients of the combined liver/small bowel graft), which were attributed to graft-versus-host disease (n = 1), posttransplant lymphoproliferative disease (n = 1), and biliary leak (n = 1). Transplantation of the intestine has evolved into a feasible operation, with an overall patient and graft survival rate of 73{\%}. These survivors are free of total parenteral nutrition, and the majority are home. These encouraging results justify further clinical trials.",
author = "J. Reyes and Tzakis, {A. G.} and S. Todo and Bakr Nour and Starzl, {T. E.}",
year = "1993",
month = "11",
language = "English",
volume = "2",
pages = "289--300",
journal = "Seminars in Pediatric Surgery",
issn = "1055-8586",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Small bowel and liver/small bowel transplantation in children.

AU - Reyes, J.

AU - Tzakis, A. G.

AU - Todo, S.

AU - Nour, Bakr

AU - Starzl, T. E.

PY - 1993/11

Y1 - 1993/11

N2 - A clinical trial of intestinal transplantation was initiated at the University of Pittsburgh in May 1990. Eleven children received either a combined liver/small bowel graft (n = 8) or an isolated small bowel graft (n = 3). Induction as well as maintenance immunosuppression was with FK-506 and steroids. Four patients were male, and seven were female; the age range was 6 months to 10.2 years. There were 3 deaths (all in recipients of the combined liver/small bowel graft), which were attributed to graft-versus-host disease (n = 1), posttransplant lymphoproliferative disease (n = 1), and biliary leak (n = 1). Transplantation of the intestine has evolved into a feasible operation, with an overall patient and graft survival rate of 73%. These survivors are free of total parenteral nutrition, and the majority are home. These encouraging results justify further clinical trials.

AB - A clinical trial of intestinal transplantation was initiated at the University of Pittsburgh in May 1990. Eleven children received either a combined liver/small bowel graft (n = 8) or an isolated small bowel graft (n = 3). Induction as well as maintenance immunosuppression was with FK-506 and steroids. Four patients were male, and seven were female; the age range was 6 months to 10.2 years. There were 3 deaths (all in recipients of the combined liver/small bowel graft), which were attributed to graft-versus-host disease (n = 1), posttransplant lymphoproliferative disease (n = 1), and biliary leak (n = 1). Transplantation of the intestine has evolved into a feasible operation, with an overall patient and graft survival rate of 73%. These survivors are free of total parenteral nutrition, and the majority are home. These encouraging results justify further clinical trials.

UR - http://www.scopus.com/inward/record.url?scp=0027701785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027701785&partnerID=8YFLogxK

M3 - Review article

VL - 2

SP - 289

EP - 300

JO - Seminars in Pediatric Surgery

JF - Seminars in Pediatric Surgery

SN - 1055-8586

IS - 4

ER -