Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy

Moulinath Banerjee, Simon G. Anderson, Rayaz Malik, Clare E. Austin, J. Kennedy Cruickshank

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

GDM (gestational diabetes mellitus) is associated with later adverse cardiovascular risk. The present study examined the relationship between glycaemia during pregnancy and small artery function and structures approx. 2 years postpartum.Women were originally enrolled in the HAPO (Hyperglycaemia and Adverse Pregnancy Outcome) study from which they were classified by their glycaemic distribution during pregnancy as controls (in the lower half of the distribution), UQ (upper quartile; in the UQ of the glycaemic distribution) or having had overt GDM. Subcutaneous arteries from a gluteal fat biopsy taken at follow-up 2 years later were examined using wire myography. Small artery structure, stiffness and vasoconstrictor responses were similar across groups. Maximal endothelium-dependent dilation in response to carbachol was impaired in arteries from both GDM (43.3%, n=8 and P=0.01) and UQ (51.7%, n=13 and P=0.04) women despite generally 'normal' current glycaemia (controls, 72.7% and n=8). Inhibition of NOS (nitric oxide synthase) significantly reduced maximum endothelium-dependent dilation in controls but had no effect on arteries from UQ and GDM women, suggesting impaired NOS activity in these groups. Endothelium-independent dilation was unaffected in arteries from previous GDM and UQ women when compared with the control group. Multiple regression analysis suggested that BMI (body mass index) at biopsy was the most potent factor independently associated with small artery function, with no effect of current glycaemia. Overweight women with either GDM or marginally raised glycaemia during pregnancy (our UQ group) had normal vascular structure and stiffness, but clearly detectable progressively impaired endothelium-dependent function at 2 years followup. These results suggest that vascular pathology, which may still be reversible, is detectable very early in women at risk of decline into Type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)53-61
Number of pages9
JournalClinical Science
Volume122
Issue number2
DOIs
Publication statusPublished - Jan 2012
Externally publishedYes

Fingerprint

Gestational Diabetes
Postpartum Period
Arteries
Pregnancy
Endothelium
Dilatation
Nitric Oxide Synthase
Myography
Biopsy
Vascular Stiffness
Carbachol
Vasoconstrictor Agents
Pregnancy Outcome
Hyperglycemia
Type 2 Diabetes Mellitus
Blood Vessels
Body Mass Index
Fats
Regression Analysis
Outcome Assessment (Health Care)

Keywords

  • Adiposity
  • Endothelial function
  • Gestational diabetes
  • Pregnancy
  • Small artery
  • Women

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy. / Banerjee, Moulinath; Anderson, Simon G.; Malik, Rayaz; Austin, Clare E.; Cruickshank, J. Kennedy.

In: Clinical Science, Vol. 122, No. 2, 01.2012, p. 53-61.

Research output: Contribution to journalArticle

Banerjee, Moulinath ; Anderson, Simon G. ; Malik, Rayaz ; Austin, Clare E. ; Cruickshank, J. Kennedy. / Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy. In: Clinical Science. 2012 ; Vol. 122, No. 2. pp. 53-61.
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