Sleep respiratory concomitants of comorbid panic and nightmare complaint in post-traumatic stress disorder

Steven H. Woodward, Gregory A. Leskin, Javaid Sheikh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Posttraumatic stress disorder (PTSD) patients with comorbid panic disorder (PD) may express additive symptoms of central fear system disturbance. They endorse elevated levels of sleep and nightmare disturbance [Leskin GA, et al., J Psychiatr Res 2002;36:449-452], and demonstrate movement suppression during laboratory sleep [Woodward SH, et al., Sleep 2002;25:681-688]. We estimated respiratory rate and rate variability separately for rapid-eye movement (REM) and non-rapid-eye movement (NREM) sleep. Subjects were 49 Vietnam combat-related PTSD inpatients (11 with comorbid PD and 38 without) and 15 controls. Computer-based estimates of respiratory rate and variability were derived from 10 to 18 hr of baseline sleep collected over two or three nights. Neither rate nor rate variability distinguished PTSD patients with comorbid PD from those without, or PTSD patients from controls; bowever PTSD patients failed to exbibit the expected differences between REM and NREM respiratory rates. Moreover, the difference between REM and NREM respiratory rate was inversely related to a continuous measure of PTSD severity. PTSD patients with trauma-related nightmare complaint exhibited higher sleep respiration rates over both REM and NREM sleep. Conversely, in addition to slowed respiration, nightmare-free patients exhibited reduced respiratory rate variability in REM relative to NREM sleep, which was a reversal of the normal pattern. These finding are discussed in light of known telencephalic regulatory influences upon respiration rate.

Original languageEnglish
Pages (from-to)198-204
Number of pages7
JournalDepression and Anxiety
Volume18
Issue number4
DOIs
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

Panic
Post-Traumatic Stress Disorders
Respiratory Rate
Sleep
REM Sleep
Eye Movements
Panic Disorder
Telencephalon
Vietnam
Fear
Inpatients
Respiration
Wounds and Injuries

Keywords

  • Anxiety
  • Panic
  • Respiration
  • Sleep
  • Stress
  • Traumatic

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Sleep respiratory concomitants of comorbid panic and nightmare complaint in post-traumatic stress disorder. / Woodward, Steven H.; Leskin, Gregory A.; Sheikh, Javaid.

In: Depression and Anxiety, Vol. 18, No. 4, 2003, p. 198-204.

Research output: Contribution to journalArticle

@article{2403a26a844a47e5aa44d3a517f7c9fe,
title = "Sleep respiratory concomitants of comorbid panic and nightmare complaint in post-traumatic stress disorder",
abstract = "Posttraumatic stress disorder (PTSD) patients with comorbid panic disorder (PD) may express additive symptoms of central fear system disturbance. They endorse elevated levels of sleep and nightmare disturbance [Leskin GA, et al., J Psychiatr Res 2002;36:449-452], and demonstrate movement suppression during laboratory sleep [Woodward SH, et al., Sleep 2002;25:681-688]. We estimated respiratory rate and rate variability separately for rapid-eye movement (REM) and non-rapid-eye movement (NREM) sleep. Subjects were 49 Vietnam combat-related PTSD inpatients (11 with comorbid PD and 38 without) and 15 controls. Computer-based estimates of respiratory rate and variability were derived from 10 to 18 hr of baseline sleep collected over two or three nights. Neither rate nor rate variability distinguished PTSD patients with comorbid PD from those without, or PTSD patients from controls; bowever PTSD patients failed to exbibit the expected differences between REM and NREM respiratory rates. Moreover, the difference between REM and NREM respiratory rate was inversely related to a continuous measure of PTSD severity. PTSD patients with trauma-related nightmare complaint exhibited higher sleep respiration rates over both REM and NREM sleep. Conversely, in addition to slowed respiration, nightmare-free patients exhibited reduced respiratory rate variability in REM relative to NREM sleep, which was a reversal of the normal pattern. These finding are discussed in light of known telencephalic regulatory influences upon respiration rate.",
keywords = "Anxiety, Panic, Respiration, Sleep, Stress, Traumatic",
author = "Woodward, {Steven H.} and Leskin, {Gregory A.} and Javaid Sheikh",
year = "2003",
doi = "10.1002/da.10075",
language = "English",
volume = "18",
pages = "198--204",
journal = "Depression and Anxiety",
issn = "1091-4269",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Sleep respiratory concomitants of comorbid panic and nightmare complaint in post-traumatic stress disorder

AU - Woodward, Steven H.

AU - Leskin, Gregory A.

AU - Sheikh, Javaid

PY - 2003

Y1 - 2003

N2 - Posttraumatic stress disorder (PTSD) patients with comorbid panic disorder (PD) may express additive symptoms of central fear system disturbance. They endorse elevated levels of sleep and nightmare disturbance [Leskin GA, et al., J Psychiatr Res 2002;36:449-452], and demonstrate movement suppression during laboratory sleep [Woodward SH, et al., Sleep 2002;25:681-688]. We estimated respiratory rate and rate variability separately for rapid-eye movement (REM) and non-rapid-eye movement (NREM) sleep. Subjects were 49 Vietnam combat-related PTSD inpatients (11 with comorbid PD and 38 without) and 15 controls. Computer-based estimates of respiratory rate and variability were derived from 10 to 18 hr of baseline sleep collected over two or three nights. Neither rate nor rate variability distinguished PTSD patients with comorbid PD from those without, or PTSD patients from controls; bowever PTSD patients failed to exbibit the expected differences between REM and NREM respiratory rates. Moreover, the difference between REM and NREM respiratory rate was inversely related to a continuous measure of PTSD severity. PTSD patients with trauma-related nightmare complaint exhibited higher sleep respiration rates over both REM and NREM sleep. Conversely, in addition to slowed respiration, nightmare-free patients exhibited reduced respiratory rate variability in REM relative to NREM sleep, which was a reversal of the normal pattern. These finding are discussed in light of known telencephalic regulatory influences upon respiration rate.

AB - Posttraumatic stress disorder (PTSD) patients with comorbid panic disorder (PD) may express additive symptoms of central fear system disturbance. They endorse elevated levels of sleep and nightmare disturbance [Leskin GA, et al., J Psychiatr Res 2002;36:449-452], and demonstrate movement suppression during laboratory sleep [Woodward SH, et al., Sleep 2002;25:681-688]. We estimated respiratory rate and rate variability separately for rapid-eye movement (REM) and non-rapid-eye movement (NREM) sleep. Subjects were 49 Vietnam combat-related PTSD inpatients (11 with comorbid PD and 38 without) and 15 controls. Computer-based estimates of respiratory rate and variability were derived from 10 to 18 hr of baseline sleep collected over two or three nights. Neither rate nor rate variability distinguished PTSD patients with comorbid PD from those without, or PTSD patients from controls; bowever PTSD patients failed to exbibit the expected differences between REM and NREM respiratory rates. Moreover, the difference between REM and NREM respiratory rate was inversely related to a continuous measure of PTSD severity. PTSD patients with trauma-related nightmare complaint exhibited higher sleep respiration rates over both REM and NREM sleep. Conversely, in addition to slowed respiration, nightmare-free patients exhibited reduced respiratory rate variability in REM relative to NREM sleep, which was a reversal of the normal pattern. These finding are discussed in light of known telencephalic regulatory influences upon respiration rate.

KW - Anxiety

KW - Panic

KW - Respiration

KW - Sleep

KW - Stress

KW - Traumatic

UR - http://www.scopus.com/inward/record.url?scp=0345824717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345824717&partnerID=8YFLogxK

U2 - 10.1002/da.10075

DO - 10.1002/da.10075

M3 - Article

C2 - 14661189

AN - SCOPUS:0345824717

VL - 18

SP - 198

EP - 204

JO - Depression and Anxiety

JF - Depression and Anxiety

SN - 1091-4269

IS - 4

ER -