Sleep apnea, reproductive hormones and quality of sexual life in severely obese men

Ahmad O. Hammoud, James M. Walker, Mark Gibson, Tom V. Cloward, Steven Hunt, Ronette L. Kolotkin, Ted D. Adams, A. Wayne Meikle

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The effect of sleep apnea on the reproductive function of obese men is not entirely elucidated. The objective of this study was to define the effect of sleep apnea on the reproductive hormones and sexual function in obese men. This study included 89 severely obese men with BMI 35kg/m 2 considering gastric bypass surgery. Anthropometrics (weight, and BMI), reproductive hormones, and sleep studies were measured. The sexual quality of life was assessed using the Impact of Weight on Quality of Life-Lite questionnaire (IWQOL-Lite). The mean age of our patients was 46.9 11.0 years, the mean BMI was 47.8 8.7kg/m 2 and the mean weight was 337.7 62.4lb. After correction for age and BMI, means of free testosterone per severity group of sleep apnea were as follows: no or mild sleep apnea 74.4 3.8pg/ml, moderate sleep apnea 68.6 4.2pg/ml, and severe sleep apnea 60.2 2.92pg/ml, P = 0.014. All other parameters of sleep apnea including hypopnea index, percent time below a SpO 2 of 90%, and percent time below a SpO 2 of 80% were also negatively correlated with testosterone levels after correction for age and BMI. BMI and presence of coronary artery disease decreased the sexual quality of life. Sleep apnea was associated with reduced sexual quality of life. In summary, sleep apnea negatively affects testosterone levels independent of BMI. Severely obese men had decreased sexual quality of life.

Original languageEnglish
Pages (from-to)1118-1123
Number of pages6
JournalObesity
Volume19
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Fingerprint

Sleep Apnea Syndromes
Quality of Life
Hormones
Testosterone
Weights and Measures
Gastric Bypass
Coronary Artery Disease
Sleep

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Hammoud, A. O., Walker, J. M., Gibson, M., Cloward, T. V., Hunt, S., Kolotkin, R. L., ... Meikle, A. W. (2011). Sleep apnea, reproductive hormones and quality of sexual life in severely obese men. Obesity, 19(6), 1118-1123. https://doi.org/10.1038/oby.2010.344

Sleep apnea, reproductive hormones and quality of sexual life in severely obese men. / Hammoud, Ahmad O.; Walker, James M.; Gibson, Mark; Cloward, Tom V.; Hunt, Steven; Kolotkin, Ronette L.; Adams, Ted D.; Meikle, A. Wayne.

In: Obesity, Vol. 19, No. 6, 06.2011, p. 1118-1123.

Research output: Contribution to journalArticle

Hammoud, AO, Walker, JM, Gibson, M, Cloward, TV, Hunt, S, Kolotkin, RL, Adams, TD & Meikle, AW 2011, 'Sleep apnea, reproductive hormones and quality of sexual life in severely obese men', Obesity, vol. 19, no. 6, pp. 1118-1123. https://doi.org/10.1038/oby.2010.344
Hammoud AO, Walker JM, Gibson M, Cloward TV, Hunt S, Kolotkin RL et al. Sleep apnea, reproductive hormones and quality of sexual life in severely obese men. Obesity. 2011 Jun;19(6):1118-1123. https://doi.org/10.1038/oby.2010.344
Hammoud, Ahmad O. ; Walker, James M. ; Gibson, Mark ; Cloward, Tom V. ; Hunt, Steven ; Kolotkin, Ronette L. ; Adams, Ted D. ; Meikle, A. Wayne. / Sleep apnea, reproductive hormones and quality of sexual life in severely obese men. In: Obesity. 2011 ; Vol. 19, No. 6. pp. 1118-1123.
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