Sleep and immunity in older age

Peter Hampson, Alessandra Rossi, Teresa Arora, Janet M. Lord, Shahrad Taheri

Research output: Chapter in Book/Report/Conference proceedingChapter


The general decline in sleep duration during the past 25 years has made suboptimal sleep quality a more common phenomenon (Jean-Louis et al., Biol Psychiatry 47:921-927, 2000). Reasons for reduced sleep include increased working hours, shift work and more time spent watching the television and exploring the internet (Bonnet and Arand, Sleep 18:908-911, 1995). Disruptions in sleep parameters have been related to a variety of health outcomes. Animal studies have shown that extreme levels of sleep deprivation are highly detrimental. Rats subjected to total sleep deprivation for up to 21 days displayed global deterioration ultimately resulting in death (Everson and Wehr, Am J Physiol 264:R376-R387, 1993). Epidemiological studies in humans have indicated that both short- and long-sleep duration is associated with increased morbidity and mortality. Most notably, a study of 1.1 million participants in the American Cancer Prevention Society demonstrated that survival was optimal in people who slept 7 h per night. Sleep durations of 8.5 h or more, or less than 4.5 h were significantly associated with increased mortality as well as higher body mass index (BMI) scores (Kripke et al., Arch Gen Psychiatry 59:131-136, 2002).

Original languageEnglish
Title of host publicationImmunosenescence: Psychosocial and Behavioral Determinants
PublisherSpringer New York
Number of pages19
ISBN (Electronic)9781461447764
ISBN (Print)1461447755, 9781461447757
Publication statusPublished - 1 May 2013
Externally publishedYes



  • Ageing
  • Immunesenescence
  • Sleep
  • Sleep quality

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Hampson, P., Rossi, A., Arora, T., Lord, J. M., & Taheri, S. (2013). Sleep and immunity in older age. In Immunosenescence: Psychosocial and Behavioral Determinants (Vol. 9781461447764, pp. 201-219). Springer New York.