Six-year changes in health-related quality of life in gastric bypass patients versus obese comparison groups

Ronette L. Kolotkin, Lance E. Davidson, Ross D. Crosby, Steven Hunt, Ted D. Adams

Research output: Contribution to journalArticle

90 Citations (Scopus)


Background: Few studies have evaluated the long-term outcomes of bariatric surgery patients in relation to obese individuals not participating in weight loss interventions. Our objective was to evaluate the 6-year changes in health-related quality of life (HRQOL) in gastric bypass (GB) patients versus 2 obese groups not undergoing surgical weight loss. The study setting was a bariatric surgery practice. Methods: A total of 323 GB patients were compared with 257 individuals who sought but did not undergo gastric bypass and 272 population-based obese individuals using weight-specific (Impact of Weight on Quality of Life-Lite) and general (Medical Outcomes Study Short-Form 36 Health Survey) HRQOL questionnaires at baseline and 2 and 6 years later. Results: At 6 years, compared with the controls, the GB group exhibited significant improvements in all domains of weight-specific and most domains of general HRQOL (i.e., all physical and some mental/psychosocial). The 6-year percentage of excess weight loss correlated significantly with improvements in both weight-specific and physical HRQOL. The HRQOL scores were fairly stable from 2 to 6 years for the GB group, with small decreases in HRQOL corresponding to some weight regain. Conclusions: GB patients demonstrated significant improvements in most aspects of HRQOL at 6 years compared with 2 nonsurgical obese groups. Despite some weight regain and small decreases in HRQOL from 2 to 6 years postoperatively, the HRQOL was relatively stable. These results support the effectiveness of weight loss achieved with gastric bypass surgery for improving and maintaining long-term HRQOL.

Original languageEnglish
Pages (from-to)625-633
Number of pages9
JournalSurgery for Obesity and Related Diseases
Issue number5
Publication statusPublished - Sep 2012
Externally publishedYes



  • Cohort trial
  • Gastric bypass surgery
  • Health-related quality of life
  • Impact of Weight on Quality of Life-Lite
  • IWQOL-Lite
  • Medical Outcomes Study Short-Form Health survey
  • SF-36

ASJC Scopus subject areas

  • Surgery

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