Significance of CD44 and CD24 as cancer stem cell markers: An enduring ambiguity

Appalaraju Jaggupilli, Eyad Elkord

Research output: Contribution to journalReview article

249 Citations (Scopus)

Abstract

Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis, heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a new insight in cancer treatment. However, prospective identification, characterization, and isolation of these CSCs have been a major challenge. Many studies were performed on surface markers for potential identification and isolation of CSCs. Lack of universal expression of surface markers limits their usage and no best combination of markers has yet been confirmed to identify CSCs capable of initiating and metastasizing tumours. CD44, a hyaluronic acid receptor, is one of the most commonly studied surface markers, which is expressed by almost every tumour cell. CD24, a heat stable antigen, is another surface marker expressed in many tumour types. However, their expression and prognostic value in isolating CSCs are still an enduring ambiguity. In this critical review, we assess the role of CD44 and CD24 in tumour initiation, development, and metastasis. We mainly focus on analysing the significance of CD44 and CD24 as CSC surface markers in combination or with other putative markers in different types of cancer.

Original languageEnglish
Article number708036
JournalClinical and Developmental Immunology
Volume2012
DOIs
Publication statusPublished - 2012
Externally publishedYes

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Neoplastic Stem Cells
Neoplasms
CD24 Antigens
Neoplasm Metastasis
Hyaluronic Acid
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Medicine(all)

Cite this

Significance of CD44 and CD24 as cancer stem cell markers : An enduring ambiguity. / Jaggupilli, Appalaraju; Elkord, Eyad.

In: Clinical and Developmental Immunology, Vol. 2012, 708036, 2012.

Research output: Contribution to journalReview article

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