Sex differences in urine metabolites related with risk of diabetes using NMR spectroscopy: results of the study of health in pomerania

Nele Friedrich, Kathrin Budde, Karsten Suhre, Uwe Völker, Ulrich John, Stephan B. Felix, Heyo K. Kroemer, Hans J. Grabe, Henry Völzke, Matthias Nauck, Henri Wallaschofski

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recently research provides evidence that blood metabolite profiles predicted type 2 diabetes. We aimed to assess the relation of urine metabolites measured via nuclear magnetic resonance spectroscopy with incident type 2 diabetes in a sample of 1353 men and 1356 women. Within 5 years, 87 men and 50 women developed diabetes. Five and 16 urine metabolites were associated with incident diabetes in men and women, respectively. Only three of these metabolites (glucose, lactate and glycine) were found in both sexes. In women, e.g. acetate, carnitine, N,N-dimethylglycine, trigonelline, 3-hydroxyisovalerate, alanine, formate, glycolate, trimethylamine N-oxide and tau-methylhistidine were positively related with diabetes. Receiver operating characteristic (ROC) analysis revealed that compared with a standard model, a model additionally adjusted for urine glucose, trigonelline and trimethylamine N-oxide levels showed a better discrimination between incident diabetes cases and non-cases in women (AUC = 0.874 and 0.903, p = 0.019). In men, valine and 4-hydroxyphenylacetate were found as markers of diabetes. However, ROC analysis did not reveal any improvement in discrimination based on urine metabolites. In conclusion, we confirmed the potential of metabolomics to assess the risk of type 2 diabetes and detected pronounced sex differences. Moreover, we demonstrated the practicability of spot urine samples as potential non-invasive diabetes screening approach.

Original languageEnglish
Pages (from-to)1405-1415
Number of pages11
JournalMetabolomics
Volume11
Issue number5
DOIs
Publication statusPublished - 7 Oct 2015
Externally publishedYes

Fingerprint

Medical problems
Metabolites
Sex Characteristics
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Health
Urine
Type 2 Diabetes Mellitus
formic acid
glycolic acid
ROC Curve
Glucose
Metabolomics
Carnitine
Valine
Alanine
Glycine
Area Under Curve
Lactic Acid
Acetates

Keywords

  • Diabetes
  • Metabolomics
  • NMR
  • Sex differences
  • Urine

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry

Cite this

Sex differences in urine metabolites related with risk of diabetes using NMR spectroscopy : results of the study of health in pomerania. / Friedrich, Nele; Budde, Kathrin; Suhre, Karsten; Völker, Uwe; John, Ulrich; Felix, Stephan B.; Kroemer, Heyo K.; Grabe, Hans J.; Völzke, Henry; Nauck, Matthias; Wallaschofski, Henri.

In: Metabolomics, Vol. 11, No. 5, 07.10.2015, p. 1405-1415.

Research output: Contribution to journalArticle

Friedrich, N, Budde, K, Suhre, K, Völker, U, John, U, Felix, SB, Kroemer, HK, Grabe, HJ, Völzke, H, Nauck, M & Wallaschofski, H 2015, 'Sex differences in urine metabolites related with risk of diabetes using NMR spectroscopy: results of the study of health in pomerania', Metabolomics, vol. 11, no. 5, pp. 1405-1415. https://doi.org/10.1007/s11306-015-0795-6
Friedrich, Nele ; Budde, Kathrin ; Suhre, Karsten ; Völker, Uwe ; John, Ulrich ; Felix, Stephan B. ; Kroemer, Heyo K. ; Grabe, Hans J. ; Völzke, Henry ; Nauck, Matthias ; Wallaschofski, Henri. / Sex differences in urine metabolites related with risk of diabetes using NMR spectroscopy : results of the study of health in pomerania. In: Metabolomics. 2015 ; Vol. 11, No. 5. pp. 1405-1415.
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