Serum uric acid is associated with carotid plaques: The National Heart, Lung, and Blood Institute Family Heart Study

Tuhina Neogi, R. Curtis Ellison, Steven Hunt, Robert Terkeltaub, David T. Felson, Yuqing Zhang

Research output: Contribution to journalArticle

60 Citations (Scopus)


Objective. To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors. Methods. The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound.We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. Results. In total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. Conclusion. In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)378-384
Number of pages7
JournalJournal of Rheumatology
Issue number2
Publication statusPublished - Feb 2009
Externally publishedYes



  • Carotid atherosclerosis
  • Epidemiology
  • Risk factors
  • Uric acid

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this