Serum uric acid is associated with carotid plaques: The National Heart, Lung, and Blood Institute Family Heart Study

Tuhina Neogi, R. Curtis Ellison, Steven Hunt, Robert Terkeltaub, David T. Felson, Yuqing Zhang

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Objective. To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors. Methods. The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound.We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. Results. In total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. Conclusion. In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)378-384
Number of pages7
JournalJournal of Rheumatology
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

Fingerprint

National Heart, Lung, and Blood Institute (U.S.)
Uric Acid
Serum
Atherosclerotic Plaques
Cardiovascular Diseases
Hyperuricemia
Rheumatology
Multicenter Studies
Heart Diseases
Atherosclerosis
Body Mass Index
Logistic Models

Keywords

  • Carotid atherosclerosis
  • Epidemiology
  • Risk factors
  • Uric acid

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Serum uric acid is associated with carotid plaques : The National Heart, Lung, and Blood Institute Family Heart Study. / Neogi, Tuhina; Ellison, R. Curtis; Hunt, Steven; Terkeltaub, Robert; Felson, David T.; Zhang, Yuqing.

In: Journal of Rheumatology, Vol. 36, No. 2, 02.2009, p. 378-384.

Research output: Contribution to journalArticle

Neogi, Tuhina ; Ellison, R. Curtis ; Hunt, Steven ; Terkeltaub, Robert ; Felson, David T. ; Zhang, Yuqing. / Serum uric acid is associated with carotid plaques : The National Heart, Lung, and Blood Institute Family Heart Study. In: Journal of Rheumatology. 2009 ; Vol. 36, No. 2. pp. 378-384.
@article{49992d79c878456d9da2575107118b40,
title = "Serum uric acid is associated with carotid plaques: The National Heart, Lung, and Blood Institute Family Heart Study",
abstract = "Objective. To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors. Methods. The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound.We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. Results. In total, 4866 participants had both SUA and carotid ultrasound assessed (54{\%} women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. Conclusion. In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men. The Journal of Rheumatology",
keywords = "Carotid atherosclerosis, Epidemiology, Risk factors, Uric acid",
author = "Tuhina Neogi and Ellison, {R. Curtis} and Steven Hunt and Robert Terkeltaub and Felson, {David T.} and Yuqing Zhang",
year = "2009",
month = "2",
doi = "10.3899/jrheum.080646",
language = "English",
volume = "36",
pages = "378--384",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "2",

}

TY - JOUR

T1 - Serum uric acid is associated with carotid plaques

T2 - The National Heart, Lung, and Blood Institute Family Heart Study

AU - Neogi, Tuhina

AU - Ellison, R. Curtis

AU - Hunt, Steven

AU - Terkeltaub, Robert

AU - Felson, David T.

AU - Zhang, Yuqing

PY - 2009/2

Y1 - 2009/2

N2 - Objective. To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors. Methods. The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound.We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. Results. In total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. Conclusion. In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men. The Journal of Rheumatology

AB - Objective. To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors. Methods. The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound.We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. Results. In total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. Conclusion. In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men. The Journal of Rheumatology

KW - Carotid atherosclerosis

KW - Epidemiology

KW - Risk factors

KW - Uric acid

UR - http://www.scopus.com/inward/record.url?scp=64849094040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64849094040&partnerID=8YFLogxK

U2 - 10.3899/jrheum.080646

DO - 10.3899/jrheum.080646

M3 - Article

C2 - 19012359

AN - SCOPUS:64849094040

VL - 36

SP - 378

EP - 384

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 2

ER -