Serial diffusion tensor imaging to characterize radiation-induced changes in normal-appearing white matter following radiotherapy in patients with adult low-grade gliomas

Mohammad Haris, Shaleen Kumar, Mani Karthick Raj, Koilpillai Joseph Maria Das, Shantanu Sapru, Sanjay Behari, Ram Kishore Singh Rathore, Ponnada A. Narayana, Rakesh Kumar Gupta

Research output: Contribution to journalArticle

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Abstract

Purpose. The aim of this study was to ascertain whether diffusion tensor imaging (DTI) metrics-fractional anisotropy (FA), mean diffusivity (MD), linear case (CL), planar case (CP), spherical case (CS)-can characterize a threshold dose and temporal evolution of changes in normal-appearing white matter (NAWM) of adults with low-grade gliomas (LGGs) treated with radiation therapy (RT). Methods and materials. Conventional and DTI imaging were performed before RT in 5 patients and subsequently, on average, at 3 months (n = 5), 8 months (n = 3), and 14 months (n = 5) following RT for a total of 18 examinations. Isodose distribution at 5-Gy intervals were visualized in all the slices of fluid attenuated inversion recovery (FLAIR) and the corresponding DTI images without diffusion sensitization (b0DTI). The latter were exported for relative quantitative analysis. Results. Compared to pre-RT values, FA and CL decreased, whereas CS increased at 3 and 8 months and recovered partially at 14 months for the dose bins > 55 Gy and 50-55 Gy. For the 45-50 Gy bin, the FA and CL decreased with an increase in CS at 3 months; no further change was seen at 8 or 14 months. For the >55 Gy and 50-55 Gy bins, CP decreased and MD increased at 3 months and returned to baseline at 8 months following RT. Conclusion. Radiation-induced changes in NAWM can be detected at 3 months after RT, with changes in FA, CL, and CS (but not CP or MD) values seen at a thresh-old dose of 45-50 Gy. A partial recovery was evident by 14 months to regions that received doses of 50-55 Gy and >55 Gy, thus providing an objective measure of radiation effect on NAWM.

Original languageEnglish
Pages (from-to)140-150
Number of pages11
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Volume26
Issue number3
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

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Diffusion Tensor Imaging
Glioma
radiation therapy
grade
Radiotherapy
Anisotropy
tensors
Radiation
radiation
diffusivity
dosage
anisotropy
recovery
Radiation Effects
radiation effects
quantitative analysis
White Matter
examination
inversions
intervals

Keywords

  • Axonal demyelination
  • Blood-brain barrier
  • Normal-appearing white matter
  • Permeability
  • Radiotherapy

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Serial diffusion tensor imaging to characterize radiation-induced changes in normal-appearing white matter following radiotherapy in patients with adult low-grade gliomas. / Haris, Mohammad; Kumar, Shaleen; Raj, Mani Karthick; Das, Koilpillai Joseph Maria; Sapru, Shantanu; Behari, Sanjay; Rathore, Ram Kishore Singh; Narayana, Ponnada A.; Gupta, Rakesh Kumar.

In: Radiation Medicine - Medical Imaging and Radiation Oncology, Vol. 26, No. 3, 04.2008, p. 140-150.

Research output: Contribution to journalArticle

Haris, Mohammad ; Kumar, Shaleen ; Raj, Mani Karthick ; Das, Koilpillai Joseph Maria ; Sapru, Shantanu ; Behari, Sanjay ; Rathore, Ram Kishore Singh ; Narayana, Ponnada A. ; Gupta, Rakesh Kumar. / Serial diffusion tensor imaging to characterize radiation-induced changes in normal-appearing white matter following radiotherapy in patients with adult low-grade gliomas. In: Radiation Medicine - Medical Imaging and Radiation Oncology. 2008 ; Vol. 26, No. 3. pp. 140-150.
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abstract = "Purpose. The aim of this study was to ascertain whether diffusion tensor imaging (DTI) metrics-fractional anisotropy (FA), mean diffusivity (MD), linear case (CL), planar case (CP), spherical case (CS)-can characterize a threshold dose and temporal evolution of changes in normal-appearing white matter (NAWM) of adults with low-grade gliomas (LGGs) treated with radiation therapy (RT). Methods and materials. Conventional and DTI imaging were performed before RT in 5 patients and subsequently, on average, at 3 months (n = 5), 8 months (n = 3), and 14 months (n = 5) following RT for a total of 18 examinations. Isodose distribution at 5-Gy intervals were visualized in all the slices of fluid attenuated inversion recovery (FLAIR) and the corresponding DTI images without diffusion sensitization (b0DTI). The latter were exported for relative quantitative analysis. Results. Compared to pre-RT values, FA and CL decreased, whereas CS increased at 3 and 8 months and recovered partially at 14 months for the dose bins > 55 Gy and 50-55 Gy. For the 45-50 Gy bin, the FA and CL decreased with an increase in CS at 3 months; no further change was seen at 8 or 14 months. For the >55 Gy and 50-55 Gy bins, CP decreased and MD increased at 3 months and returned to baseline at 8 months following RT. Conclusion. Radiation-induced changes in NAWM can be detected at 3 months after RT, with changes in FA, CL, and CS (but not CP or MD) values seen at a thresh-old dose of 45-50 Gy. A partial recovery was evident by 14 months to regions that received doses of 50-55 Gy and >55 Gy, thus providing an objective measure of radiation effect on NAWM.",
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AU - Haris, Mohammad

AU - Kumar, Shaleen

AU - Raj, Mani Karthick

AU - Das, Koilpillai Joseph Maria

AU - Sapru, Shantanu

AU - Behari, Sanjay

AU - Rathore, Ram Kishore Singh

AU - Narayana, Ponnada A.

AU - Gupta, Rakesh Kumar

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N2 - Purpose. The aim of this study was to ascertain whether diffusion tensor imaging (DTI) metrics-fractional anisotropy (FA), mean diffusivity (MD), linear case (CL), planar case (CP), spherical case (CS)-can characterize a threshold dose and temporal evolution of changes in normal-appearing white matter (NAWM) of adults with low-grade gliomas (LGGs) treated with radiation therapy (RT). Methods and materials. Conventional and DTI imaging were performed before RT in 5 patients and subsequently, on average, at 3 months (n = 5), 8 months (n = 3), and 14 months (n = 5) following RT for a total of 18 examinations. Isodose distribution at 5-Gy intervals were visualized in all the slices of fluid attenuated inversion recovery (FLAIR) and the corresponding DTI images without diffusion sensitization (b0DTI). The latter were exported for relative quantitative analysis. Results. Compared to pre-RT values, FA and CL decreased, whereas CS increased at 3 and 8 months and recovered partially at 14 months for the dose bins > 55 Gy and 50-55 Gy. For the 45-50 Gy bin, the FA and CL decreased with an increase in CS at 3 months; no further change was seen at 8 or 14 months. For the >55 Gy and 50-55 Gy bins, CP decreased and MD increased at 3 months and returned to baseline at 8 months following RT. Conclusion. Radiation-induced changes in NAWM can be detected at 3 months after RT, with changes in FA, CL, and CS (but not CP or MD) values seen at a thresh-old dose of 45-50 Gy. A partial recovery was evident by 14 months to regions that received doses of 50-55 Gy and >55 Gy, thus providing an objective measure of radiation effect on NAWM.

AB - Purpose. The aim of this study was to ascertain whether diffusion tensor imaging (DTI) metrics-fractional anisotropy (FA), mean diffusivity (MD), linear case (CL), planar case (CP), spherical case (CS)-can characterize a threshold dose and temporal evolution of changes in normal-appearing white matter (NAWM) of adults with low-grade gliomas (LGGs) treated with radiation therapy (RT). Methods and materials. Conventional and DTI imaging were performed before RT in 5 patients and subsequently, on average, at 3 months (n = 5), 8 months (n = 3), and 14 months (n = 5) following RT for a total of 18 examinations. Isodose distribution at 5-Gy intervals were visualized in all the slices of fluid attenuated inversion recovery (FLAIR) and the corresponding DTI images without diffusion sensitization (b0DTI). The latter were exported for relative quantitative analysis. Results. Compared to pre-RT values, FA and CL decreased, whereas CS increased at 3 and 8 months and recovered partially at 14 months for the dose bins > 55 Gy and 50-55 Gy. For the 45-50 Gy bin, the FA and CL decreased with an increase in CS at 3 months; no further change was seen at 8 or 14 months. For the >55 Gy and 50-55 Gy bins, CP decreased and MD increased at 3 months and returned to baseline at 8 months following RT. Conclusion. Radiation-induced changes in NAWM can be detected at 3 months after RT, with changes in FA, CL, and CS (but not CP or MD) values seen at a thresh-old dose of 45-50 Gy. A partial recovery was evident by 14 months to regions that received doses of 50-55 Gy and >55 Gy, thus providing an objective measure of radiation effect on NAWM.

KW - Axonal demyelination

KW - Blood-brain barrier

KW - Normal-appearing white matter

KW - Permeability

KW - Radiotherapy

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