Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles

C. J.T. Visser, M. G.J. Tilanus, V. Schaeffer, Zohreh Tatari Calderone, R. Tamouza, A. Janin, D. Charron

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The MHC class I chain-related gene A (MICA) is highly polymorphic. In this paper we demonstrate polymorphism in the other expressing member of the MIC family of genes: MICB. Using a sequencing-based typing approach on cDNA, analysis of exons 2 through 6 revealed eight polymorphic sites resulting in six unique MICB sequences. Although MICB has high nucleotide homology with MICA, its polymorphism is restricted and at different sites compared to those in MICA.

Original languageEnglish
Pages (from-to)649-652
Number of pages4
JournalTissue Antigens
Volume51
Issue number6
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Alleles
Genes
MHC Class I Genes
Exons
Nucleotides
Complementary DNA

Keywords

  • MICB
  • Polymorphic sites
  • Sequence-based typing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Genetics

Cite this

Visser, C. J. T., Tilanus, M. G. J., Schaeffer, V., Tatari Calderone, Z., Tamouza, R., Janin, A., & Charron, D. (1998). Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles. Tissue Antigens, 51(6), 649-652.

Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles. / Visser, C. J.T.; Tilanus, M. G.J.; Schaeffer, V.; Tatari Calderone, Zohreh; Tamouza, R.; Janin, A.; Charron, D.

In: Tissue Antigens, Vol. 51, No. 6, 1998, p. 649-652.

Research output: Contribution to journalArticle

Visser, CJT, Tilanus, MGJ, Schaeffer, V, Tatari Calderone, Z, Tamouza, R, Janin, A & Charron, D 1998, 'Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles', Tissue Antigens, vol. 51, no. 6, pp. 649-652.
Visser CJT, Tilanus MGJ, Schaeffer V, Tatari Calderone Z, Tamouza R, Janin A et al. Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles. Tissue Antigens. 1998;51(6):649-652.
Visser, C. J.T. ; Tilanus, M. G.J. ; Schaeffer, V. ; Tatari Calderone, Zohreh ; Tamouza, R. ; Janin, A. ; Charron, D. / Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles. In: Tissue Antigens. 1998 ; Vol. 51, No. 6. pp. 649-652.
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