Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles

C. J.T. Visser, M. G.J. Tilanus, V. Schaeffer, Z. Tatari, R. Tamouza, A. Janin, D. Charron

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The MHC class I chain-related gene A (MICA) is highly polymorphic. In this paper we demonstrate polymorphism in the other expressing member of the MIC family of genes: MICB. Using a sequencing-based typing approach on cDNA, analysis of exons 2 through 6 revealed eight polymorphic sites resulting in six unique MICB sequences. Although MICB has high nucleotide homology with MICA, its polymorphism is restricted and at different sites compared to those in MICA.

Original languageEnglish
Pages (from-to)649-652
Number of pages4
JournalTissue Antigens
Volume51
Issue number6
DOIs
Publication statusPublished - 1 Jan 1998

    Fingerprint

Keywords

  • MICB
  • Polymorphic sites
  • Sequence-based typing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

Visser, C. J. T., Tilanus, M. G. J., Schaeffer, V., Tatari, Z., Tamouza, R., Janin, A., & Charron, D. (1998). Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles. Tissue Antigens, 51(6), 649-652. https://doi.org/10.1111/j.1399-0039.1998.tb03008.x