Sensitive Spectroscopic Analysis of Biomarkers in Exhaled Breath

A. Bicer, J. Bounds, F. Zhu, A. A. Kolomenskii, N. Kaya, E. Aluauee, Mahmood Amani, H. A. Schuessler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We have developed a novel optical setup which is based on a high finesse cavity and absorption laser spectroscopy in the near-IR spectral region. In pilot experiments, spectrally resolved absorption measurements of biomarkers in exhaled breath, such as methane and acetone, were carried out using cavity ring-down spectroscopy (CRDS). With a 172-cm-long cavity, an efficient optical path of ~ 132 km was achieved. The CRDS technique is well suited for such measurements due to its high sensitivity and good spectral resolution. The detection limits for methane of ~ 8 ppbv and acetone of ~ 2.1 ppbv with spectral sampling of 0.005 cm−1 were achieved, which allowed to analyze multicomponent gas mixtures and to observe absorption peaks of 12CH4 and 13CH4. Further improvements of the technique have the potential to realize diagnostics of health conditions based on a multicomponent analysis of breath samples.

Original languageEnglish
Article number69
JournalInternational Journal of Thermophysics
Volume39
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

Fingerprint

biomarkers
spectroscopic analysis
cavities
acetone
methane
rings
optical paths
laser spectroscopy
spectral resolution
spectroscopy
health
gas mixtures
absorption spectroscopy
sampling
sensitivity

Keywords

  • Absorption spectroscopy
  • Breath analysis
  • Cavity ring-down

ASJC Scopus subject areas

  • Condensed Matter Physics

Cite this

Bicer, A., Bounds, J., Zhu, F., Kolomenskii, A. A., Kaya, N., Aluauee, E., ... Schuessler, H. A. (2018). Sensitive Spectroscopic Analysis of Biomarkers in Exhaled Breath. International Journal of Thermophysics, 39(6), [69]. https://doi.org/10.1007/s10765-018-2389-9

Sensitive Spectroscopic Analysis of Biomarkers in Exhaled Breath. / Bicer, A.; Bounds, J.; Zhu, F.; Kolomenskii, A. A.; Kaya, N.; Aluauee, E.; Amani, Mahmood; Schuessler, H. A.

In: International Journal of Thermophysics, Vol. 39, No. 6, 69, 01.06.2018.

Research output: Contribution to journalArticle

Bicer, A, Bounds, J, Zhu, F, Kolomenskii, AA, Kaya, N, Aluauee, E, Amani, M & Schuessler, HA 2018, 'Sensitive Spectroscopic Analysis of Biomarkers in Exhaled Breath', International Journal of Thermophysics, vol. 39, no. 6, 69. https://doi.org/10.1007/s10765-018-2389-9
Bicer, A. ; Bounds, J. ; Zhu, F. ; Kolomenskii, A. A. ; Kaya, N. ; Aluauee, E. ; Amani, Mahmood ; Schuessler, H. A. / Sensitive Spectroscopic Analysis of Biomarkers in Exhaled Breath. In: International Journal of Thermophysics. 2018 ; Vol. 39, No. 6.
@article{13402abf834f4442bdfe7e81038a2e9a,
title = "Sensitive Spectroscopic Analysis of Biomarkers in Exhaled Breath",
abstract = "We have developed a novel optical setup which is based on a high finesse cavity and absorption laser spectroscopy in the near-IR spectral region. In pilot experiments, spectrally resolved absorption measurements of biomarkers in exhaled breath, such as methane and acetone, were carried out using cavity ring-down spectroscopy (CRDS). With a 172-cm-long cavity, an efficient optical path of ~ 132 km was achieved. The CRDS technique is well suited for such measurements due to its high sensitivity and good spectral resolution. The detection limits for methane of ~ 8 ppbv and acetone of ~ 2.1 ppbv with spectral sampling of 0.005 cm−1 were achieved, which allowed to analyze multicomponent gas mixtures and to observe absorption peaks of 12CH4 and 13CH4. Further improvements of the technique have the potential to realize diagnostics of health conditions based on a multicomponent analysis of breath samples.",
keywords = "Absorption spectroscopy, Breath analysis, Cavity ring-down",
author = "A. Bicer and J. Bounds and F. Zhu and Kolomenskii, {A. A.} and N. Kaya and E. Aluauee and Mahmood Amani and Schuessler, {H. A.}",
year = "2018",
month = "6",
day = "1",
doi = "10.1007/s10765-018-2389-9",
language = "English",
volume = "39",
journal = "International Journal of Thermophysics",
issn = "0195-928X",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Sensitive Spectroscopic Analysis of Biomarkers in Exhaled Breath

AU - Bicer, A.

AU - Bounds, J.

AU - Zhu, F.

AU - Kolomenskii, A. A.

AU - Kaya, N.

AU - Aluauee, E.

AU - Amani, Mahmood

AU - Schuessler, H. A.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - We have developed a novel optical setup which is based on a high finesse cavity and absorption laser spectroscopy in the near-IR spectral region. In pilot experiments, spectrally resolved absorption measurements of biomarkers in exhaled breath, such as methane and acetone, were carried out using cavity ring-down spectroscopy (CRDS). With a 172-cm-long cavity, an efficient optical path of ~ 132 km was achieved. The CRDS technique is well suited for such measurements due to its high sensitivity and good spectral resolution. The detection limits for methane of ~ 8 ppbv and acetone of ~ 2.1 ppbv with spectral sampling of 0.005 cm−1 were achieved, which allowed to analyze multicomponent gas mixtures and to observe absorption peaks of 12CH4 and 13CH4. Further improvements of the technique have the potential to realize diagnostics of health conditions based on a multicomponent analysis of breath samples.

AB - We have developed a novel optical setup which is based on a high finesse cavity and absorption laser spectroscopy in the near-IR spectral region. In pilot experiments, spectrally resolved absorption measurements of biomarkers in exhaled breath, such as methane and acetone, were carried out using cavity ring-down spectroscopy (CRDS). With a 172-cm-long cavity, an efficient optical path of ~ 132 km was achieved. The CRDS technique is well suited for such measurements due to its high sensitivity and good spectral resolution. The detection limits for methane of ~ 8 ppbv and acetone of ~ 2.1 ppbv with spectral sampling of 0.005 cm−1 were achieved, which allowed to analyze multicomponent gas mixtures and to observe absorption peaks of 12CH4 and 13CH4. Further improvements of the technique have the potential to realize diagnostics of health conditions based on a multicomponent analysis of breath samples.

KW - Absorption spectroscopy

KW - Breath analysis

KW - Cavity ring-down

UR - http://www.scopus.com/inward/record.url?scp=85046169700&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046169700&partnerID=8YFLogxK

U2 - 10.1007/s10765-018-2389-9

DO - 10.1007/s10765-018-2389-9

M3 - Article

VL - 39

JO - International Journal of Thermophysics

JF - International Journal of Thermophysics

SN - 0195-928X

IS - 6

M1 - 69

ER -