Sensitive electrochemical detection of l-cysteine based on a highly stable Pd@Ti3C2T:X(MXene) nanocomposite modified glassy carbon electrode

P. Abdul Rasheed, Ravi P. Pandey, Khadeeja A. Jabbar, Janarthanan Ponraj, Khaled Mahmoud

Research output: Contribution to journalArticle

Abstract

Rapid and real-time detection of l-cysteine (l-Cys) is important for early diagnostics of several diseases and biological disorders. We report here a stable and highly sensitive electrochemical sensor for the detection of l-Cys based on a Pd@Ti3C2Tx (MXene)-modified glassy carbon electrode (GCE). The Pd@Ti3C2Tx nanocomposite was prepared by in situ reduction of Pd(ii) salt on the surface of delaminated (DL) Ti3C2Tx nanosheets to form pseudo-spherical palladium nanoparticles (PdNPs) with 2-6 nm size distributions. The MXene acts as the conductive matrix and a reducing agent at the electrode surface, while PdNPs are there to improve the stability of Ti3C2Tx and to enhance the electrocatalytic activity towards l-Cys detection. The Pd@Ti3C2Tx/GCE sensor exhibited a detection limit of 0.14 μM and a linear electro-oxidative response to l-Cys within the concentration range from 0.5 to 10 μM. The sensor also demonstrated excellent selectivity over common interfering ions such as ascorbic acid, uric acid, dopamine and glucose.

Original languageEnglish
Pages (from-to)3851-3856
Number of pages6
JournalAnalytical Methods
Volume11
Issue number30
DOIs
Publication statusPublished - 14 Aug 2019

Fingerprint

Glassy carbon
Cysteine
Nanocomposites
Palladium
Electrodes
Nanoparticles
Electrochemical sensors
Nanosheets
Ascorbic acid
Reducing Agents
Sensors
Reducing agents
Uric Acid
Ascorbic Acid
Glucose
Dopamine
Salts
Ions
Acids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemical Engineering(all)
  • Engineering(all)

Cite this

Sensitive electrochemical detection of l-cysteine based on a highly stable Pd@Ti3C2T:X(MXene) nanocomposite modified glassy carbon electrode. / Rasheed, P. Abdul; Pandey, Ravi P.; Jabbar, Khadeeja A.; Ponraj, Janarthanan; Mahmoud, Khaled.

In: Analytical Methods, Vol. 11, No. 30, 14.08.2019, p. 3851-3856.

Research output: Contribution to journalArticle

Rasheed, P. Abdul ; Pandey, Ravi P. ; Jabbar, Khadeeja A. ; Ponraj, Janarthanan ; Mahmoud, Khaled. / Sensitive electrochemical detection of l-cysteine based on a highly stable Pd@Ti3C2T:X(MXene) nanocomposite modified glassy carbon electrode. In: Analytical Methods. 2019 ; Vol. 11, No. 30. pp. 3851-3856.
@article{7aaa0710e3b644139c343632d7dadaea,
title = "Sensitive electrochemical detection of l-cysteine based on a highly stable Pd@Ti3C2T:X(MXene) nanocomposite modified glassy carbon electrode",
abstract = "Rapid and real-time detection of l-cysteine (l-Cys) is important for early diagnostics of several diseases and biological disorders. We report here a stable and highly sensitive electrochemical sensor for the detection of l-Cys based on a Pd@Ti3C2Tx (MXene)-modified glassy carbon electrode (GCE). The Pd@Ti3C2Tx nanocomposite was prepared by in situ reduction of Pd(ii) salt on the surface of delaminated (DL) Ti3C2Tx nanosheets to form pseudo-spherical palladium nanoparticles (PdNPs) with 2-6 nm size distributions. The MXene acts as the conductive matrix and a reducing agent at the electrode surface, while PdNPs are there to improve the stability of Ti3C2Tx and to enhance the electrocatalytic activity towards l-Cys detection. The Pd@Ti3C2Tx/GCE sensor exhibited a detection limit of 0.14 μM and a linear electro-oxidative response to l-Cys within the concentration range from 0.5 to 10 μM. The sensor also demonstrated excellent selectivity over common interfering ions such as ascorbic acid, uric acid, dopamine and glucose.",
author = "Rasheed, {P. Abdul} and Pandey, {Ravi P.} and Jabbar, {Khadeeja A.} and Janarthanan Ponraj and Khaled Mahmoud",
year = "2019",
month = "8",
day = "14",
doi = "10.1039/c9ay00912d",
language = "English",
volume = "11",
pages = "3851--3856",
journal = "Analytical Methods",
issn = "1759-9660",
publisher = "Royal Society of Chemistry",
number = "30",

}

TY - JOUR

T1 - Sensitive electrochemical detection of l-cysteine based on a highly stable Pd@Ti3C2T:X(MXene) nanocomposite modified glassy carbon electrode

AU - Rasheed, P. Abdul

AU - Pandey, Ravi P.

AU - Jabbar, Khadeeja A.

AU - Ponraj, Janarthanan

AU - Mahmoud, Khaled

PY - 2019/8/14

Y1 - 2019/8/14

N2 - Rapid and real-time detection of l-cysteine (l-Cys) is important for early diagnostics of several diseases and biological disorders. We report here a stable and highly sensitive electrochemical sensor for the detection of l-Cys based on a Pd@Ti3C2Tx (MXene)-modified glassy carbon electrode (GCE). The Pd@Ti3C2Tx nanocomposite was prepared by in situ reduction of Pd(ii) salt on the surface of delaminated (DL) Ti3C2Tx nanosheets to form pseudo-spherical palladium nanoparticles (PdNPs) with 2-6 nm size distributions. The MXene acts as the conductive matrix and a reducing agent at the electrode surface, while PdNPs are there to improve the stability of Ti3C2Tx and to enhance the electrocatalytic activity towards l-Cys detection. The Pd@Ti3C2Tx/GCE sensor exhibited a detection limit of 0.14 μM and a linear electro-oxidative response to l-Cys within the concentration range from 0.5 to 10 μM. The sensor also demonstrated excellent selectivity over common interfering ions such as ascorbic acid, uric acid, dopamine and glucose.

AB - Rapid and real-time detection of l-cysteine (l-Cys) is important for early diagnostics of several diseases and biological disorders. We report here a stable and highly sensitive electrochemical sensor for the detection of l-Cys based on a Pd@Ti3C2Tx (MXene)-modified glassy carbon electrode (GCE). The Pd@Ti3C2Tx nanocomposite was prepared by in situ reduction of Pd(ii) salt on the surface of delaminated (DL) Ti3C2Tx nanosheets to form pseudo-spherical palladium nanoparticles (PdNPs) with 2-6 nm size distributions. The MXene acts as the conductive matrix and a reducing agent at the electrode surface, while PdNPs are there to improve the stability of Ti3C2Tx and to enhance the electrocatalytic activity towards l-Cys detection. The Pd@Ti3C2Tx/GCE sensor exhibited a detection limit of 0.14 μM and a linear electro-oxidative response to l-Cys within the concentration range from 0.5 to 10 μM. The sensor also demonstrated excellent selectivity over common interfering ions such as ascorbic acid, uric acid, dopamine and glucose.

UR - http://www.scopus.com/inward/record.url?scp=85070206476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070206476&partnerID=8YFLogxK

U2 - 10.1039/c9ay00912d

DO - 10.1039/c9ay00912d

M3 - Article

AN - SCOPUS:85070206476

VL - 11

SP - 3851

EP - 3856

JO - Analytical Methods

JF - Analytical Methods

SN - 1759-9660

IS - 30

ER -