Semen of HIV-1-infected individuals

Local shedding of herpesviruses and reprogrammed cytokine network

Andrea Lisco, Arshi Munawwar, Andrea Introini, Christophe Vanpouille, Elisa Saba, Xingmin Feng, Jean-Charles B. Grivel, Sarman Singh, Leonid Margolis

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background. Semen is the main carrier of sexually transmitted viruses, including human immunodeficiency virus type 1 (HIV-1). However, semen is not just a mere passive transporter of virions but also plays an active role in HIV-1 transmission through cytokines and other biological factors. Methods. To study the relationship between viruses and the chemokine-cytokine network in the male genital tract, we measured the concentrations of 21 cytokines/chemokines and the loads of HIV-1 and of 6 herpesviruses in seminal and blood plasma from HIV-1-infected and HIV-uninfected men. Results. We found that (1) semen is enriched in cytokines and chemokines that play key roles in HIV-1 infection or transmission; (2) HIV-1 infection changes the chemokine-cytokine network in semen, further enriching it in cytokines that modulate its replication; (3) HIV-1 infection is associated with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) compartmentalized seminal reactivation; (4) CMV and EBV concomitant seminal shedding is associated with higher HIV-1 loads in blood and seminal plasma; and (5) CMV seminal reactivation increases the seminal levels of the CCR5 ligands RANTES and eotaxin, and of the CXCR3 ligand monokine induced by gamma interferon (MIG). Conclusions. HIV-1 infection results in an aberrant production of cytokines and reactivation of EBV and CMV that further changes the seminal cytokine network. The altered seminal milieu in HIV-1 infection may be a determinant of HIV-1 sexual transmission.

Original languageEnglish
Pages (from-to)97-105
Number of pages9
JournalJournal of Infectious Diseases
Volume205
Issue number1
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

Fingerprint

Herpesviridae
Semen
HIV-1
Cytokines
Virus Diseases
Cytomegalovirus
Chemokines
Human Herpesvirus 4
Monokines
Ligands
Viruses
Chemokine CCL5
Infectious Disease Transmission
Biological Factors
Virion
Interferon-gamma
HIV

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Lisco, A., Munawwar, A., Introini, A., Vanpouille, C., Saba, E., Feng, X., ... Margolis, L. (2012). Semen of HIV-1-infected individuals: Local shedding of herpesviruses and reprogrammed cytokine network. Journal of Infectious Diseases, 205(1), 97-105. https://doi.org/10.1093/infdis/jir700

Semen of HIV-1-infected individuals : Local shedding of herpesviruses and reprogrammed cytokine network. / Lisco, Andrea; Munawwar, Arshi; Introini, Andrea; Vanpouille, Christophe; Saba, Elisa; Feng, Xingmin; Grivel, Jean-Charles B.; Singh, Sarman; Margolis, Leonid.

In: Journal of Infectious Diseases, Vol. 205, No. 1, 01.01.2012, p. 97-105.

Research output: Contribution to journalArticle

Lisco, A, Munawwar, A, Introini, A, Vanpouille, C, Saba, E, Feng, X, Grivel, J-CB, Singh, S & Margolis, L 2012, 'Semen of HIV-1-infected individuals: Local shedding of herpesviruses and reprogrammed cytokine network', Journal of Infectious Diseases, vol. 205, no. 1, pp. 97-105. https://doi.org/10.1093/infdis/jir700
Lisco, Andrea ; Munawwar, Arshi ; Introini, Andrea ; Vanpouille, Christophe ; Saba, Elisa ; Feng, Xingmin ; Grivel, Jean-Charles B. ; Singh, Sarman ; Margolis, Leonid. / Semen of HIV-1-infected individuals : Local shedding of herpesviruses and reprogrammed cytokine network. In: Journal of Infectious Diseases. 2012 ; Vol. 205, No. 1. pp. 97-105.
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