Selective nanomolar detection of dopamine using a boron-doped diamond electrode modified with an electropolymerized sulfobutylether-β- cyclodextrin-doped poly(N-acetyltyramine) and polypyrrole composite film

Fengjun Shang, Lin Zhou, Khaled Mahmoud, Sabahudin Hrapovic, Yali Liu, Humphrey A. Moynihan, Jeremy D. Glennon, John H T Luong

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

N-Acetyltyramine was synthesized and electropolymerized together with a negatively charged sulfobutylether-β-cyclodextrin on a boron-doped diamond (BDD) electrode followed by the electropolymerization of pyrrole to form a stable and permselective film for selective dopamine detection. The selectivity and sensitivity of the formed layer-by-layer film was governed by the sequence of deposition and the applied potential. Raman results showed a decrease in the peak intensity at 1329 cm-1 (sp3), the main feature of BDD, upon each electrodeposition step. Such a decrease was correlated well with the change of the charge-transfer resistance derived from impedance data, i.e., reflecting the formation of the layer-by-layer film. The polycrystalline BDD surface became more even with lower surface roughness as revealed by scanning electron and atomic force microscopy. The modified BDD electrode exhibited rapid response to dopamine within 1.5-2 s and a low detection limit of 4-5 nM with excellent reproducibility. Electroactive interferences caused by 4-dihydroxyphenylalanine, 3,4-dihydroxyphenylacetic acid, ascorbic acid, and uric acid were completely eliminated, whereas the signal response of epinephrine and norepinephrine was significantly suppressed by the permselective film.

Original languageEnglish
Pages (from-to)4089-4098
Number of pages10
JournalAnalytical Chemistry
Volume81
Issue number10
DOIs
Publication statusPublished - 15 May 2009
Externally publishedYes

Fingerprint

Diamond
Boron
Cyclodextrins
Composite films
Dopamine
Electrodes
Atomic Force Microscopy
Electroplating
3,4-Dihydroxyphenylacetic Acid
Dihydroxyphenylalanine
Pyrroles
Electropolymerization
Uric Acid
Electric Impedance
Electrodeposition
Epinephrine
Ascorbic Acid
Limit of Detection
Charge transfer
Atomic force microscopy

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Selective nanomolar detection of dopamine using a boron-doped diamond electrode modified with an electropolymerized sulfobutylether-β- cyclodextrin-doped poly(N-acetyltyramine) and polypyrrole composite film. / Shang, Fengjun; Zhou, Lin; Mahmoud, Khaled; Hrapovic, Sabahudin; Liu, Yali; Moynihan, Humphrey A.; Glennon, Jeremy D.; Luong, John H T.

In: Analytical Chemistry, Vol. 81, No. 10, 15.05.2009, p. 4089-4098.

Research output: Contribution to journalArticle

Shang, Fengjun ; Zhou, Lin ; Mahmoud, Khaled ; Hrapovic, Sabahudin ; Liu, Yali ; Moynihan, Humphrey A. ; Glennon, Jeremy D. ; Luong, John H T. / Selective nanomolar detection of dopamine using a boron-doped diamond electrode modified with an electropolymerized sulfobutylether-β- cyclodextrin-doped poly(N-acetyltyramine) and polypyrrole composite film. In: Analytical Chemistry. 2009 ; Vol. 81, No. 10. pp. 4089-4098.
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