Selective inhibition of nociceptive flexion reflex discharge by the kappa agonist bremazocine

N. R. Banna, Hassen Al Amin, S. J. Jabbur

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In unanaesthetized decerebrate spinal cats, bremazocine (0.012-0.2 mg/kg i.v.) selectively inhibited the late C-fibre reflex discharge, recorded in sectioned lumbo-sacral ventral root filaments, after supramaximal electrical stimulation of the ipsilateral sural or common peroneal nerve. This action was naloxone-reversible. The results suggest that activation of kappa opioid receptors in the spinal cord inhibits the integration of nociceptive, but not locomotor, flexion reflexes.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalNeuropharmacology
Volume26
Issue number2-3
DOIs
Publication statusPublished - 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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