Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors

Bruce C. Trapnell, Paul Tolstoshev, Ronald G. Crystal

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Thermodynamically stable secondary structures have been found for adjacent splice junctions of 17 introns from 10 eukaryotic and viral mRNA precursors. Complementary regions in these structures position the exons to be ligated in a favourable orientation for splicing. The possible role of these structures in a general splicing mechanism is described.

Original languageEnglish
Pages (from-to)3659-3672
Number of pages14
JournalNucleic acids research
Issue number16
Publication statusPublished - 25 Aug 1980


ASJC Scopus subject areas

  • Genetics

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