Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors

Bruce C. Trapnell, Paul Tolstoshev, Ronald G. Crystal

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Thermodynamically stable secondary structures have been found for adjacent splice junctions of 17 introns from 10 eukaryotic and viral mRNA precursors. Complementary regions in these structures position the exons to be ligated in a favourable orientation for splicing. The possible role of these structures in a general splicing mechanism is described.

Original languageEnglish
Pages (from-to)3659-3672
Number of pages14
JournalNucleic Acids Research
Volume8
Issue number16
DOIs
Publication statusPublished - 25 Aug 1980
Externally publishedYes

Fingerprint

RNA Precursors
Viral RNA
Introns
Exons
Messenger RNA

ASJC Scopus subject areas

  • Genetics

Cite this

Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors. / Trapnell, Bruce C.; Tolstoshev, Paul; Crystal, Ronald G.

In: Nucleic Acids Research, Vol. 8, No. 16, 25.08.1980, p. 3659-3672.

Research output: Contribution to journalArticle

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