Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM

Makoto Daimon, Hidenori Sato, Satoshi Sasaki, Sayumi Toriyama, Mitsuru Emi, Masaaki Muramatsu, Steven C. Hunt, Paul N. Hopkins, Shigeru Karasawa, Kiriko Wada, Yumi Jimbu, Wataru Kameda, Shinji Susa, Toshihide Oizumi, Akira Fukao, Isao Kubota, Sumio Kawata, Takeo Kato

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Abstract

The associations of the C825T polymorphism (rs5443) of the G-protein β3 subunit (GNB3) gene and eight adjacent single nucleotide polymorphisms (SNPs) with diabetes were examined using a Japanese population (n (M/W): 2956 (1335/1621); age: 63.0 ± 10.2 years). Fasting plasma glucose (FPG) levels were significantly associated with the C825T polymorphism and two flanking SNPs (rs2301339 and rs5446) (p = 0.002, 0.001, and 0.008, respectively). A case-control association study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT + TC with an odds ratio of 0.62 (p = 0.008) independent of age, gender, and BMI. The effects of salt consumption on the association were then examined (n = 1635). The FPG levels were significantly associated with the C825T polymorphism only in subjects with low salt consumption (<12.44 g/day) (p = 0.002). A case-control association study also showed a significant association with diabetes only in subjects with low salt consumption (p = 0.006).

Original languageEnglish
Pages (from-to)576-580
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume374
Issue number3
DOIs
Publication statusPublished - 26 Sep 2008

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Keywords

  • G-protein β3 subunit
  • Gene environment relationship
  • Genetic variation
  • Hypertension
  • Population-based study
  • SNP
  • Salt consumption
  • Sodium-proton exchanger
  • Takahata study
  • Type 2 diabetes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Daimon, M., Sato, H., Sasaki, S., Toriyama, S., Emi, M., Muramatsu, M., Hunt, S. C., Hopkins, P. N., Karasawa, S., Wada, K., Jimbu, Y., Kameda, W., Susa, S., Oizumi, T., Fukao, A., Kubota, I., Kawata, S., & Kato, T. (2008). Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM. Biochemical and Biophysical Research Communications, 374(3), 576-580. https://doi.org/10.1016/j.bbrc.2008.07.065