Salivary and serum androgens with anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome

Thozhukat Sathyapalan, Ahmed Al-Qaissi, Eric S. Kilpatrick, Soha Dargham, Brian Keevil, Stephen Atkin

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Abstract

To determine the predictive value of a raised androgen level with an elevated anti-Müllerian hormone (AMH) for the diagnosis or exclusion of polycystic ovary syndrome (PCOS), a prospective cross-sectional study of 170 women (105 with PCOS type A and 65 normal) was undertaken. AMH was combined with one of, total serum testosterone (T); calculated free androgen index; salivary testosterone (salT); serum androstenedione (A); salivary androstenedione (salA). The diagnostic sensitivity and specificity of AMH (>35 pmol/l) alone for PCOS were 55% and 79% respectively. The diagnostic sensitivity and specificity of AMH (>35 pmol/l) with either an elevated T or raised FAI level for PCOS showed 100% specificity and a 100% positive predictive value. Conversely, diagnostic exclusion of PCOS was shown by an AMH <35 pmol/l with a normal T or FAI salivary testosterone giving 100% specificity and 100% positive predictive value. AMH with an elevated A or elevated salA level gave specificities of 87% and 94%, and positive predictive values 80% and 94%, respectively. Therefore, the combination of an AMH with a cut off of 35 pmol/l combined with a raised T and/or a FAI will confirm PCOS whilst a normal AMH with a normal T and/or FAI will exclude PCOS, thus addressing diagnostic uncertainty.

Original languageEnglish
Article number3795
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Dec 2018

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Polycystic Ovary Syndrome
Androgens
Hormones
Serum
Androstenedione
Testosterone
Sensitivity and Specificity
Uncertainty
Cross-Sectional Studies

ASJC Scopus subject areas

  • General

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Salivary and serum androgens with anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome. / Sathyapalan, Thozhukat; Al-Qaissi, Ahmed; Kilpatrick, Eric S.; Dargham, Soha; Keevil, Brian; Atkin, Stephen.

In: Scientific Reports, Vol. 8, No. 1, 3795, 01.12.2018.

Research output: Contribution to journalArticle

Sathyapalan, Thozhukat ; Al-Qaissi, Ahmed ; Kilpatrick, Eric S. ; Dargham, Soha ; Keevil, Brian ; Atkin, Stephen. / Salivary and serum androgens with anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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