rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease

Zohreh Tatari Calderone, Caterina P. Minniti, Tonya Kratovil, Milica Stojakovic, Alison Vollmer, Igor Barjaktarevic, Ed Zhang, Albert Hoang, Naomi L.C. Luban, Stanislav Vukmanovic

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Patients with sickle cell disease (SCD) who receive red blood cell (RBC) transfusions have a higher rate of anti-RBC (allo and auto) antibody development than other transfused subjects. We hypothesized that an incidence and/or kinetics of RBC-specific antibody formation in SCD patients is influenced by a linked inheritance of the hemoglobin beta S (HbβS) allele and a polymorphism rs660C/T in the neighboring Ro52 gene. We found that 75% of C/T heterozygous and only 30.8% of T/T homozygous patients that developed antibodies were first transfused before the age of five. In addition, there was a significant inverse correlation between time of exposure to antigen or number of transfusions received and the age when T/T patients received first transfusion, indicating progressive development of competence of their immune system. In contrast, this correlation was not observed in patients with C/T genotype. Finally, increased expression of Ro52 was associated with the presence of the T/T genotype. These results suggest that rs660 polymorphism is a marker of efficiency of tolerance induction in early childhood and immune competence development to RBC antigens in SCD patients of pre-teen/teen age.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalMolecular Immunology
Volume47
Issue number1
DOIs
Publication statusPublished - Nov 2009
Externally publishedYes

Fingerprint

Sickle Cell Anemia
Erythrocytes
Mental Competency
Genotype
Sickle Hemoglobin
Antigens
Erythrocyte Transfusion
Antibodies
Antibody Formation
Immune System
Alleles
Incidence
Genes

Keywords

  • Antibodies
  • Gene polymorphisms
  • Red blood cell transfusion
  • Sickle cell disease

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

Cite this

rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease. / Tatari Calderone, Zohreh; Minniti, Caterina P.; Kratovil, Tonya; Stojakovic, Milica; Vollmer, Alison; Barjaktarevic, Igor; Zhang, Ed; Hoang, Albert; Luban, Naomi L.C.; Vukmanovic, Stanislav.

In: Molecular Immunology, Vol. 47, No. 1, 11.2009, p. 64-70.

Research output: Contribution to journalReview article

Tatari Calderone, Z, Minniti, CP, Kratovil, T, Stojakovic, M, Vollmer, A, Barjaktarevic, I, Zhang, E, Hoang, A, Luban, NLC & Vukmanovic, S 2009, 'rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease', Molecular Immunology, vol. 47, no. 1, pp. 64-70. https://doi.org/10.1016/j.molimm.2008.12.027
Tatari Calderone, Zohreh ; Minniti, Caterina P. ; Kratovil, Tonya ; Stojakovic, Milica ; Vollmer, Alison ; Barjaktarevic, Igor ; Zhang, Ed ; Hoang, Albert ; Luban, Naomi L.C. ; Vukmanovic, Stanislav. / rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease. In: Molecular Immunology. 2009 ; Vol. 47, No. 1. pp. 64-70.
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AU - Vollmer, Alison

AU - Barjaktarevic, Igor

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