Rotating frame spin lattice relaxation in a swine model of chronic, left ventricular myocardial infarction

Walter R T Witschey, James J. Pilla, Giovanni Ferrari, Kevin Koomalsingh, Mohammad Haris, Robin Hinmon, Gerald Zsido, Joseph H. Gorman, Robert C. Gorman, Ravinder Reddy

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Abstract

T1? relaxation times were quantified in a swine model of chronic, left ventricular myocardial infarction. It was found that there were low frequency relaxation mechanisms that suppress endogenous contrast at low spin-lock amplitudes and in T2-weighted images. A moderate amplitude spin-locking pulse could overcome these relaxation mechanisms. Relaxation dispersion data were measured over a range of RF field amplitudes, and a model was formulated to include dipole-dipole relaxation modulated by molecular rotation and an apparent exchange mechanism. These techniques may find some use in the clinic for the observation of chronic, left ventricular cardiac remodeling.

Original languageEnglish
Pages (from-to)1454-1461
Number of pages8
JournalMagnetic Resonance in Medicine
Volume64
Issue number5
DOIs
Publication statusPublished - Nov 2010
Externally publishedYes

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Keywords

  • Magnetic resonance imaging
  • Myocardial infarction
  • Spin lock
  • T1?
  • T2

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Witschey, W. R. T., Pilla, J. J., Ferrari, G., Koomalsingh, K., Haris, M., Hinmon, R., Zsido, G., Gorman, J. H., Gorman, R. C., & Reddy, R. (2010). Rotating frame spin lattice relaxation in a swine model of chronic, left ventricular myocardial infarction. Magnetic Resonance in Medicine, 64(5), 1454-1461. https://doi.org/10.1002/mrm.22543