Role of vitamin D beyond the skeletal function

A review of the molecular and clinical studies

Meenakshi Umar, Seetharama S. Konduru, Aouatef I. Chouchane

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The classical function of Vitamin D, which involves mineral balance and skeletal maintenance, has been known for many years. With the discovery of vitamin D receptors in various tissues, several other biological functions of vitamin D are increasingly recognized and its role in many human diseases like cancer, diabetes, hypertension, cardiovascular, and autoimmune and dermatological diseases is being extensively explored. The non-classical function of vitamin D involves regulation of cellular proliferation, differentiation, apoptosis, and innate and adaptive immunity. In this review, we discuss and summarize the latest findings on the non-classical functions of vitamin D at the cellular/molecular level and its role in complex human diseases.

Original languageEnglish
Article number1618
JournalInternational Journal of Molecular Sciences
Volume19
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

Fingerprint

calciferol
Vitamins
Vitamin D
Calcitriol Receptors
Adaptive Immunity
hypertension
Medical problems
Innate Immunity
Autoimmune Diseases
Minerals
immunity
apoptosis
Cell death
Maintenance
Cell Proliferation
maintenance
Tissue
Apoptosis
Hypertension
cancer

Keywords

  • Cellular functions
  • Clinical effect
  • Immune regulation
  • Non-phosphocalcic action
  • Vitamin D

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Role of vitamin D beyond the skeletal function : A review of the molecular and clinical studies. / Umar, Meenakshi; Konduru, Seetharama S.; Chouchane, Aouatef I.

In: International Journal of Molecular Sciences, Vol. 19, No. 6, 1618, 01.06.2018.

Research output: Contribution to journalReview article

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