Role of vitamin D beyond the skeletal function: A review of the molecular and clinical studies

Meenakshi Umar, Seetharama S. Konduru, Aouatef I. Chouchane

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

The classical function of Vitamin D, which involves mineral balance and skeletal maintenance, has been known for many years. With the discovery of vitamin D receptors in various tissues, several other biological functions of vitamin D are increasingly recognized and its role in many human diseases like cancer, diabetes, hypertension, cardiovascular, and autoimmune and dermatological diseases is being extensively explored. The non-classical function of vitamin D involves regulation of cellular proliferation, differentiation, apoptosis, and innate and adaptive immunity. In this review, we discuss and summarize the latest findings on the non-classical functions of vitamin D at the cellular/molecular level and its role in complex human diseases.

Original languageEnglish
Article number1618
JournalInternational Journal of Molecular Sciences
Volume19
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

    Fingerprint

Keywords

  • Cellular functions
  • Clinical effect
  • Immune regulation
  • Non-phosphocalcic action
  • Vitamin D

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this