Role of the NLRP3 inflammasome in cancer

Maryam Moossavi, Negin Parsamanesh, Afsane Bahrami, Stephen Atkin, Amirhossein Sahebkar

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy.

Original languageEnglish
Number of pages1
JournalMolecular Cancer
Volume17
Issue number1
DOIs
Publication statusPublished - 17 Nov 2018

Fingerprint

Inflammasomes
Caspase 1
Neoplasms
Intracellular Signaling Peptides and Proteins
Interleukin-1
Peptide Hydrolases
Apoptosis
Cytokines
Proteins

Keywords

  • Apoptosis-associated speck-like protein
  • Caspase-1
  • Interleukin-1β
  • Nod-like receptor protein 3

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

Cite this

Moossavi, M., Parsamanesh, N., Bahrami, A., Atkin, S., & Sahebkar, A. (2018). Role of the NLRP3 inflammasome in cancer. Molecular Cancer, 17(1). https://doi.org/10.1186/s12943-018-0900-3

Role of the NLRP3 inflammasome in cancer. / Moossavi, Maryam; Parsamanesh, Negin; Bahrami, Afsane; Atkin, Stephen; Sahebkar, Amirhossein.

In: Molecular Cancer, Vol. 17, No. 1, 17.11.2018.

Research output: Contribution to journalReview article

Moossavi, M, Parsamanesh, N, Bahrami, A, Atkin, S & Sahebkar, A 2018, 'Role of the NLRP3 inflammasome in cancer', Molecular Cancer, vol. 17, no. 1. https://doi.org/10.1186/s12943-018-0900-3
Moossavi M, Parsamanesh N, Bahrami A, Atkin S, Sahebkar A. Role of the NLRP3 inflammasome in cancer. Molecular Cancer. 2018 Nov 17;17(1). https://doi.org/10.1186/s12943-018-0900-3
Moossavi, Maryam ; Parsamanesh, Negin ; Bahrami, Afsane ; Atkin, Stephen ; Sahebkar, Amirhossein. / Role of the NLRP3 inflammasome in cancer. In: Molecular Cancer. 2018 ; Vol. 17, No. 1.
@article{489814bfe7314a54ace99590ebbf899d,
title = "Role of the NLRP3 inflammasome in cancer",
abstract = "Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy.",
keywords = "Apoptosis-associated speck-like protein, Caspase-1, Interleukin-1β, Nod-like receptor protein 3",
author = "Maryam Moossavi and Negin Parsamanesh and Afsane Bahrami and Stephen Atkin and Amirhossein Sahebkar",
year = "2018",
month = "11",
day = "17",
doi = "10.1186/s12943-018-0900-3",
language = "English",
volume = "17",
journal = "Molecular Cancer",
issn = "1476-4598",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Role of the NLRP3 inflammasome in cancer

AU - Moossavi, Maryam

AU - Parsamanesh, Negin

AU - Bahrami, Afsane

AU - Atkin, Stephen

AU - Sahebkar, Amirhossein

PY - 2018/11/17

Y1 - 2018/11/17

N2 - Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy.

AB - Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy.

KW - Apoptosis-associated speck-like protein

KW - Caspase-1

KW - Interleukin-1β

KW - Nod-like receptor protein 3

UR - http://www.scopus.com/inward/record.url?scp=85056591264&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056591264&partnerID=8YFLogxK

U2 - 10.1186/s12943-018-0900-3

DO - 10.1186/s12943-018-0900-3

M3 - Review article

VL - 17

JO - Molecular Cancer

JF - Molecular Cancer

SN - 1476-4598

IS - 1

ER -