Role of the NLRP3 inflammasome in cancer

Maryam Moossavi, Negin Parsamanesh, Afsane Bahrami, Stephen Atkin, Amirhossein Sahebkar

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy.

Original languageEnglish
Number of pages1
JournalMolecular Cancer
Volume17
Issue number1
DOIs
Publication statusPublished - 17 Nov 2018

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Keywords

  • Apoptosis-associated speck-like protein
  • Caspase-1
  • Interleukin-1β
  • Nod-like receptor protein 3

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

Cite this

Moossavi, M., Parsamanesh, N., Bahrami, A., Atkin, S., & Sahebkar, A. (2018). Role of the NLRP3 inflammasome in cancer. Molecular Cancer, 17(1). https://doi.org/10.1186/s12943-018-0900-3