Role of the neurotrophin network in eating disorders' subphenotypes: Body mass index and age at onset of the disease

Mònica Gratacòs, Geòrgia Escaramís, Mariona Bustamante, Ester Saus, Zaida Agüera, Mònica Bayés, Elena Cellini, Rafael de Cid, Fernando Fernández-Aranda, Laura Forcano, Juan R. González, Philip Gorwood, Johannes Hebebrand, Anke Hinney, Josep M. Mercader, Benedetta Nacmias, Nicolas Ramoz, Marta Ribasés, Valdo Ricca, Lucia RomoSandro Sorbi, Audrey Versini, Xavier P. Estivill

Research output: Contribution to journalArticle

5 Citations (Scopus)


Eating disorders (ED) are severe psychiatric diseases that most likely result from, and are sustained by socio-cultural, psychological and biological factors. We explored whether members of the neurotrophin family are disease-modifying factors of quantitative traits, potentially contributing to the outcome or prognosis of the disease. We studied lifetime minimum and maximum body mass index (minBMI and maxBMI) and age at onset of the disease in a sample of 991 ED patients from France, Germany, Italy and Spain and analysed 183 genetic variants located in 10 candidate genes encoding different neurotrophins and their receptors. We used a hierarchical model approach to include prior genetic knowledge of the specific and found that variants in CNTF, in its receptor CNTFR, and in NTRK2 were significantly associated with a lower age at onset of the ED. In addition, one variant in NTRK1 was associated with a higher minBMI. The results suggest that for these two subphenotypes, CNTF, CNTFR, NTRK1 and NTRK2 might act as disease-modifying factors and add preliminary evidence to the global hypothesis that EDs are the result of complex interactions and reciprocal controls between the immune, endocrine and central nervous systems.

Original languageEnglish
Pages (from-to)834-840
Number of pages7
JournalJournal of Psychiatric Research
Issue number13
Publication statusPublished - Oct 2010
Externally publishedYes



  • Association
  • Eating disorders
  • Hierarchical model
  • Neurotrophins
  • Polymorphism
  • Subphenotypes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Gratacòs, M., Escaramís, G., Bustamante, M., Saus, E., Agüera, Z., Bayés, M., Cellini, E., Cid, R. D., Fernández-Aranda, F., Forcano, L., González, J. R., Gorwood, P., Hebebrand, J., Hinney, A., Mercader, J. M., Nacmias, B., Ramoz, N., Ribasés, M., Ricca, V., ... Estivill, X. P. (2010). Role of the neurotrophin network in eating disorders' subphenotypes: Body mass index and age at onset of the disease. Journal of Psychiatric Research, 44(13), 834-840.