Role of the microenvironment in ovarian cancer stem cell maintenance

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Despite recent progresses in cancer therapy and increased knowledge in cancer biology, ovarian cancer remains a challenging condition. Among the latest concepts developed in cancer biology, cancer stem cells and the role of microenvironment in tumor progression seem to be related. Indeed, cancer stem cells have been described in several solid tumors including ovarian cancers. These particular cells have the ability to self-renew and reconstitute a heterogeneous tumor. They are characterized by specific surface markers and display resistance to therapeutic regimens. During development, specific molecular cues from the tumor microenvironment can play a role in maintaining and expanding stemness of cancer cells. The tumor stroma contains several compartments: cellular component, cytokine network, and extracellular matrix. These different compartments interact to form a permissive niche for the cancer stem cells. Understanding the molecular cues underlying this crosstalk will allow the design of new therapeutic regimens targeting the niche. In this paper, we will discuss the mechanisms implicated in the interaction between ovarian cancer stem cells and their microenvironment.

Original languageEnglish
Article number630782
JournalBioMed Research International
Volume2013
DOIs
Publication statusPublished - 2013

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Neoplastic Stem Cells
Stem cells
Ovarian Neoplasms
Tumors
Maintenance
Neoplasms
Stem Cell Niche
Cues
Crosstalk
Aptitude
Display devices
Tumor Microenvironment
Cells
Cytokines
Extracellular Matrix
Therapeutics

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Role of the microenvironment in ovarian cancer stem cell maintenance. / Pasquier, Jennifer; Tabrizi, Arash Rafii.

In: BioMed Research International, Vol. 2013, 630782, 2013.

Research output: Contribution to journalReview article

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