Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population

Rohit Upadhyay, Amal Robay, Khalid Adnan Mohamed A. Fakhro, Abi A. Khalil, Mahmoud Zirie, Amin Jayyousi, Maha El-Shafei, Szilard Kiss, Donald J. D'Amico, Jacqueline Salit, Michelle R. Staudt, Sarah L. O'Beirne, Xiaoliang Chen, Balwant Tuana, Ronald Crystal, Hong Ding

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Overexpression of SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. In this study our primary objective is to explore the role of SLMAP gene polymorphisms in the susceptibility of type 2 diabetes (T2DM) with or without diabetic retinopathy (DR) in the Qatari population. Methods: A total of 342 Qatari subjects (non-diabetic controls and T2DM patients with or without DR) were genotyped for SLMAP gene polymorphisms (rs17058639 C > T. rs1043045 C > T and rs1057719 A > G) using Taqman SNP genotyping assay. Results: SLMAP rs17058639 C > T polymorphism was associated with the presence of DR among Qataris with T2DM. One-way ANOVA and multiple logistic regression analysis showed SLMAP SNP rs17058639 C > T as an independent risk factor for DR development. SLMAP rs17058639 C > T polymorphism also had a predictive role for the severity of DR. Haplotype Crs17058639Trs1043045Ars1057719 was associated with the increased risk for DR among Qataris with T2DM. Conclusions: The data suggests the potential role of SLMAP SNPs as a risk factor for the susceptibility of DR among T2DM patients in the Qatari population.

Original languageEnglish
Article number61
JournalJournal of Translational Medicine
Volume13
Issue number1
DOIs
Publication statusPublished - 15 Feb 2015

    Fingerprint

Keywords

  • Diabetic retinopathy
  • Endothelial dysfunction
  • Genetic susceptibility
  • Qatari population
  • SLMAP
  • T2DM

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Upadhyay, R., Robay, A., Fakhro, K. A. M. A., Khalil, A. A., Zirie, M., Jayyousi, A., El-Shafei, M., Kiss, S., D'Amico, D. J., Salit, J., Staudt, M. R., O'Beirne, S. L., Chen, X., Tuana, B., Crystal, R., & Ding, H. (2015). Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population. Journal of Translational Medicine, 13(1), [61]. https://doi.org/10.1186/s12967-015-0411-6