Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Ajaz A. Bhat, Salma N. Younes, Syed Shadab Raza, Lubna Zarif, Sabah Nisar, Ikhlak Ahmed, Rashid Mir, Sachin Kumar, Surender K. Sharawat, Sheema Hashem, Imadeldin Elfaki, Michal Kulinski, Shilpa Kuttikrishnan, Kirti S. Prabhu, Abdul Q. Khan, Santosh K. Yadav, Wael El-Rifai, Mohammad A. Zargar, Hatem Zayed, Mohammad HarisShahab Uddin

Research output: Contribution to journalReview article

Abstract

Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate. Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with the development and progression of various cancers, including leukemia. In this review, we highlight the expression and functional roles of different types of non-coding RNAs in leukemia and discuss their potential clinical applications as diagnostic or prognostic biomarkers and therapeutic targets.

Original languageEnglish
Article number57
JournalMolecular cancer
Volume19
Issue number1
DOIs
Publication statusPublished - 12 Mar 2020

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Keywords

  • Cancer
  • Chromatin
  • Circular RNAs
  • Drug resistance
  • Epigenetics
  • Gene regulation
  • Long non-coding RNAs
  • Metastasis
  • MicroRNAs
  • Signaling pathways

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

Cite this

Bhat, A. A., Younes, S. N., Raza, S. S., Zarif, L., Nisar, S., Ahmed, I., Mir, R., Kumar, S., Sharawat, S. K., Hashem, S., Elfaki, I., Kulinski, M., Kuttikrishnan, S., Prabhu, K. S., Khan, A. Q., Yadav, S. K., El-Rifai, W., Zargar, M. A., Zayed, H., ... Uddin, S. (2020). Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance. Molecular cancer, 19(1), [57]. https://doi.org/10.1186/s12943-020-01175-9