Role of NO in vascular smooth muscle and cardiac muscle function

Richard Schulz, Chris R. Triggle

Research output: Contribution to journalReview article

95 Citations (Scopus)


NO is a key transducer of a vasodilator message from the endothelium to vascular smooth muscle. Recently, its actions as a negative inotrope in cardiac muscle have been discovered. In the vasculature, it is synthesized under physiological conditions following activation of a low-output, Ca2+-dependent NO synthase (NOS) in endothelial cells. Immune activation triggers the expression of a high-output, Ca2+-independent NOS in the vasculature and myocardium, causing the overproduction of NO and significant cardiovscular dysfunction. In this article, Richard Schulz and Chris Triggle briefly review recent findings concerning the role of NO, and other endothelium-derived factors, in vascular smooth muscle function and consider the consequences of its production in the heart.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalTrends in Pharmacological Sciences
Issue number7
Publication statusPublished - Jul 1994


ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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