Role of NO in vascular smooth muscle and cardiac muscle function

Richard Schulz, Christopher Triggle

Research output: Contribution to journalReview article

95 Citations (Scopus)

Abstract

NO is a key transducer of a vasodilator message from the endothelium to vascular smooth muscle. Recently, its actions as a negative inotrope in cardiac muscle have been discovered. In the vasculature, it is synthesized under physiological conditions following activation of a low-output, Ca2+-dependent NO synthase (NOS) in endothelial cells. Immune activation triggers the expression of a high-output, Ca2+-independent NOS in the vasculature and myocardium, causing the overproduction of NO and significant cardiovscular dysfunction. In this article, Richard Schulz and Chris Triggle briefly review recent findings concerning the role of NO, and other endothelium-derived factors, in vascular smooth muscle function and consider the consequences of its production in the heart.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalTrends in Pharmacological Sciences
Volume15
Issue number7
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Vascular Smooth Muscle
Nitric Oxide Synthase
Endothelium
Muscle
Myocardium
Transducers
Chemical activation
Vasodilator Agents
Endothelial Cells
Endothelial cells

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Role of NO in vascular smooth muscle and cardiac muscle function. / Schulz, Richard; Triggle, Christopher.

In: Trends in Pharmacological Sciences, Vol. 15, No. 7, 1994, p. 255-259.

Research output: Contribution to journalReview article

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