Role of myosin light chain (MLC) phosphorylation in an-giotensin II (AII)-dependent enhancement of a-adrenoceptor-mediated contraction of rat tail artery smooth muscle cells

S. K. O'Neill, X. F. Li, C. R. Triggle

Research output: Contribution to journalArticle

Abstract

It is well established that MLC phosphorylation plays a key role in the regulation of smooth muscle contraction. It is also well established that All, and a number of other factors, at concentrations too low to initiate a direct contractile response, can enhance vascular smooth muscle contraction. We have previously shown that All can enhance the increase in Ca2+i; the signal (measured with Fura 2) initiated by a-adrenoceptor agonists. We have also shown that the same low concentration of All can enhance phosphorylation of MLC without initiating a contraction of the tissue. In the present study we have investigated the dose dependency on the effects of All on MLC phosphorylation in rat tail artery tissues.

Original languageEnglish
Number of pages1
JournalProceedings of the Western Pharmacology Society
Volume40
Publication statusPublished - 1 Dec 1997

ASJC Scopus subject areas

  • Pharmacology

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