Abstract
Background: Ovarian cancer is the deadliest gynaecologic malignancy. Despite progresses in chemotherapy and ultra-radical surgeries, this locally metastatic disease presents a high rate of local recurrence advocating for the role of a peritoneal niche. For several years, it was believed that tumor initiation, progression and metastasis were merely due to the changes in the neoplastic cell population and the adjacent non-neoplastic tissues were regarded as bystanders. The importance of the tumor microenvironment and its cellular component emerged from studies on the histopathological sequence of changes at the interface between putative tumor cells and the surrounding non-neoplastic tissues during carcinogenesis.Method: In this review we aimed to describe the pro-tumoral crosstalk between ovarian cancer and mesenchymal stem cells. A PubMed search was performed for articles published pertaining to mesenchymal stem cells and specific to ovarian cancer.Results: Mesenchymal stem cells participate to an elaborate crosstalk through direct and paracrine interaction with ovarian cancer cells. They play a role at different stages of the disease: survival and peritoneal infiltration at early stage, proliferation in distant sites, chemoresistance and recurrence at later stage.Conclusion: The dialogue between ovarian and mesenchymal stem cells induces the constitution of a pro-tumoral mesencrine niche. Understanding the dynamics of such interaction in a clinical setting might propose new therapeutic strategies.
| Original language | English |
|---|---|
| Article number | 271 |
| Journal | Journal of Translational Medicine |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 11 Oct 2014 |
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Keywords
- Chemoresistance
- Crosstalk
- Dissemination
- Mesenchymal stem cells
- Ovarian cancer
- Phenotypic modulation
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Role of mesenchymal cells in the natural history of ovarian cancer : A review. / Touboul, Cyril; Vidal, Fabien; Pasquier, Jennifer; Lis, Raphael; Tabrizi, Arash Rafii.
In: Journal of Translational Medicine, Vol. 12, No. 1, 271, 11.10.2014.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Role of mesenchymal cells in the natural history of ovarian cancer
T2 - A review
AU - Touboul, Cyril
AU - Vidal, Fabien
AU - Pasquier, Jennifer
AU - Lis, Raphael
AU - Tabrizi, Arash Rafii
PY - 2014/10/11
Y1 - 2014/10/11
N2 - Background: Ovarian cancer is the deadliest gynaecologic malignancy. Despite progresses in chemotherapy and ultra-radical surgeries, this locally metastatic disease presents a high rate of local recurrence advocating for the role of a peritoneal niche. For several years, it was believed that tumor initiation, progression and metastasis were merely due to the changes in the neoplastic cell population and the adjacent non-neoplastic tissues were regarded as bystanders. The importance of the tumor microenvironment and its cellular component emerged from studies on the histopathological sequence of changes at the interface between putative tumor cells and the surrounding non-neoplastic tissues during carcinogenesis.Method: In this review we aimed to describe the pro-tumoral crosstalk between ovarian cancer and mesenchymal stem cells. A PubMed search was performed for articles published pertaining to mesenchymal stem cells and specific to ovarian cancer.Results: Mesenchymal stem cells participate to an elaborate crosstalk through direct and paracrine interaction with ovarian cancer cells. They play a role at different stages of the disease: survival and peritoneal infiltration at early stage, proliferation in distant sites, chemoresistance and recurrence at later stage.Conclusion: The dialogue between ovarian and mesenchymal stem cells induces the constitution of a pro-tumoral mesencrine niche. Understanding the dynamics of such interaction in a clinical setting might propose new therapeutic strategies.
AB - Background: Ovarian cancer is the deadliest gynaecologic malignancy. Despite progresses in chemotherapy and ultra-radical surgeries, this locally metastatic disease presents a high rate of local recurrence advocating for the role of a peritoneal niche. For several years, it was believed that tumor initiation, progression and metastasis were merely due to the changes in the neoplastic cell population and the adjacent non-neoplastic tissues were regarded as bystanders. The importance of the tumor microenvironment and its cellular component emerged from studies on the histopathological sequence of changes at the interface between putative tumor cells and the surrounding non-neoplastic tissues during carcinogenesis.Method: In this review we aimed to describe the pro-tumoral crosstalk between ovarian cancer and mesenchymal stem cells. A PubMed search was performed for articles published pertaining to mesenchymal stem cells and specific to ovarian cancer.Results: Mesenchymal stem cells participate to an elaborate crosstalk through direct and paracrine interaction with ovarian cancer cells. They play a role at different stages of the disease: survival and peritoneal infiltration at early stage, proliferation in distant sites, chemoresistance and recurrence at later stage.Conclusion: The dialogue between ovarian and mesenchymal stem cells induces the constitution of a pro-tumoral mesencrine niche. Understanding the dynamics of such interaction in a clinical setting might propose new therapeutic strategies.
KW - Chemoresistance
KW - Crosstalk
KW - Dissemination
KW - Mesenchymal stem cells
KW - Ovarian cancer
KW - Phenotypic modulation
UR - http://www.scopus.com/inward/record.url?scp=84908062896&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908062896&partnerID=8YFLogxK
U2 - 10.1186/s12967-014-0271-5
DO - 10.1186/s12967-014-0271-5
M3 - Review article
C2 - 25303976
AN - SCOPUS:84908062896
VL - 12
JO - Journal of Translational Medicine
JF - Journal of Translational Medicine
SN - 1479-5876
IS - 1
M1 - 271
ER -