Role of humoral presensitization in human renal transplant rejection

P. Gailiunas, Manikkam Suthanthiran, G. J. Busch

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A prospective study of 31 cadaveric renal allograft recipients was performed to determine the significance of pretransplant presensitization undetected by the conventional microlymphocytotoxicity crossmatch. Donor-specific humoral presensitization revealed by the antibody-dependent cell-mediated cytotoxicity assay (ADCC) was associated with a high incidence of early graft rejection. Six-month graft survival was 20% in recipients with positive pretransplant ADCC and 75% in ADCC-negative recipients (P < 0.01). Among recipients highly presensitized to a random panel of HLA antigens, donor-specific humoral presensitization detected by chromium-51-release complement-dependent cytotoxicity (51Cr-CDC) was also highly correlated with accelerated rejection (P < 0.05). Pathologic study of the rejected allografts revealed antibody-mediated rejection vasculitis in all recipients. The authors conclude that humoral presensitization undetected by current conventional methods plays a cardinal role in early renal graft rejection and is a major factor responsible for low cadaveric renal transplant survival. This study suggests that use of the ADCC and 51Cr-CDC as routine adjunctive cross-match procedures may contribute to improvement in renal transplant survival rates.

Original languageEnglish
Pages (from-to)638-646
Number of pages9
JournalKidney International
Volume17
Issue number5
DOIs
Publication statusPublished - 1 Jan 1980
Externally publishedYes

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Antibody-Dependent Cell Cytotoxicity
Graft Rejection
Kidney
Centers for Disease Control and Prevention (U.S.)
Allografts
Transplants
Chromium
Graft Survival
HLA Antigens
Vasculitis
Survival Rate
Prospective Studies
Antibodies
Incidence

ASJC Scopus subject areas

  • Nephrology

Cite this

Role of humoral presensitization in human renal transplant rejection. / Gailiunas, P.; Suthanthiran, Manikkam; Busch, G. J.

In: Kidney International, Vol. 17, No. 5, 01.01.1980, p. 638-646.

Research output: Contribution to journalArticle

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