Role of humoral presensitization in human renal transplant rejection

P. Gailiunas, M. Suthanthiran, G. J. Busch

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A prospective study of 31 cadaveric renal allograft recipients was performed to determine the significance of pretransplant presensitization undetected by the conventional microlymphocytotoxicity crossmatch. Donor-specific humoral presensitization revealed by the antibody-dependent cell-mediated cytotoxicity assay (ADCC) was associated with a high incidence of early graft rejection. Six-month graft survival was 20% in recipients with positive pretransplant ADCC and 75% in ADCC-negative recipients (P < 0.01). Among recipients highly presensitized to a random panel of HLA antigens, donor-specific humoral presensitization detected by chromium-51-release complement-dependent cytotoxicity (51Cr-CDC) was also highly correlated with accelerated rejection (P < 0.05). Pathologic study of the rejected allografts revealed antibody-mediated rejection vasculitis in all recipients. The authors conclude that humoral presensitization undetected by current conventional methods plays a cardinal role in early renal graft rejection and is a major factor responsible for low cadaveric renal transplant survival. This study suggests that use of the ADCC and 51Cr-CDC as routine adjunctive cross-match procedures may contribute to improvement in renal transplant survival rates.

Original languageEnglish
Pages (from-to)638-646
Number of pages9
JournalKidney International
Volume17
Issue number5
DOIs
Publication statusPublished - 1 Jan 1980

ASJC Scopus subject areas

  • Nephrology

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