Role of cholesterol in parasitic infections

Devendra Bansal, Harinderpal Singh Bhatti, Rakesh Sehgal

Research output: Contribution to journalReview article

59 Citations (Scopus)

Abstract

The requirement of cholesterol for internalization of eukaryotic pathogens like protozoa (Leishmaniasis, Malaria and Toxoplasmosis) and the exchange of cholesterol along with other metabolites during reproduction in Schistosomes (helminths) under variable circumstances are poorly understood. In patients infected with some other helminthes, alterations in the lipid profile have been observed. Also, the mechanisms involved in lipid changes especially in membrane proteins related to parasite infections remain uncertain. Present review of literature shows that parasites induce significant changes in lipid parameters, as has been shown in the in vitro study where substitution of serum by lipid/cholesterol in medium and in experimental models (in vivo). Thus changes in lipid profile occur in patients having active infections with most of the parasites. Membrane proteins are probably involved in such reactions. All parasites may be metabolising cholesterol, but the exact relationship with pathogenic mechanism is not clear. So far, studies suggest that there may be some factors or enzymes, which allow the parasite to breakup and consume lipid/cholesterol. Further studies are needed for better understanding of the mechanisms involved in vivo. The present review analysis the various studies till date and the role of cholesterol in pathogenesis of different parasitic infections.

Original languageEnglish
Article number10
JournalLipids in Health and Disease
Volume4
DOIs
Publication statusPublished - 9 May 2005
Externally publishedYes

Fingerprint

Parasitic Diseases
Cholesterol
Lipids
Parasites
Membrane Proteins
Protozoa
Leishmaniasis
Helminths
Toxoplasmosis
Pathogens
Metabolites
Malaria
Reproduction
Substitution reactions
Theoretical Models
Enzymes
Infection
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Role of cholesterol in parasitic infections. / Bansal, Devendra; Bhatti, Harinderpal Singh; Sehgal, Rakesh.

In: Lipids in Health and Disease, Vol. 4, 10, 09.05.2005.

Research output: Contribution to journalReview article

Bansal, Devendra ; Bhatti, Harinderpal Singh ; Sehgal, Rakesh. / Role of cholesterol in parasitic infections. In: Lipids in Health and Disease. 2005 ; Vol. 4.
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