Role of animal research in human malignancies

Abdul Q. Khan, Kodappully S. Siveen, Kirti S. Prabhu, Shilpa Kuttikrishnan, Sabah Akhtar, Muralitharan Shanmugakonar, Hamda A. Al-Naemi, Mohammad Haris, Shahab Uddin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Animal models are the central backbone in relation to providing the safety information of xenobiotics, the nature of chemicals present in the environment, and understanding the developmental process in disease pathogenesis of most of the health issues of humans and in drug development. This chapter describes the therapeutic importance of the animal models of human cancers. Rodents, particularly mice and rats, are the most widely used animals in the development of experimental models to benefit humans. Centuries ago, identification of the first chemical carcinogens and elucidation of carcinogenesis was carried out in rodents. Since then, investigations, mostly on mice, have revealed the multistep process of tumorigenesis, central to identification and understanding of the underlying mechanisms, genetic manipulation studies, identification of novel anticancer compounds, and development of noninvasive imaging technology for early diagnosis, etc., all convergent towards improving human health.

Original languageEnglish
Title of host publicationAnimal Models in Cancer Drug Discovery
PublisherElsevier
Pages1-29
Number of pages29
ISBN (Electronic)9780128147054
ISBN (Print)9780128147047
DOIs
Publication statusPublished - 17 Apr 2019

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Keywords

  • Animal model
  • Cancer
  • Carcinogenesis
  • Genetic engineering
  • Noninvasive imaging
  • Rodents
  • Xenografts

ASJC Scopus subject areas

  • Economics, Econometrics and Finance(all)
  • Business, Management and Accounting(all)

Cite this

Khan, A. Q., Siveen, K. S., Prabhu, K. S., Kuttikrishnan, S., Akhtar, S., Shanmugakonar, M., Al-Naemi, H. A., Haris, M., & Uddin, S. (2019). Role of animal research in human malignancies. In Animal Models in Cancer Drug Discovery (pp. 1-29). Elsevier. https://doi.org/10.1016/B978-0-12-814704-7.00003-9