In this work, first, a Region of Interest (ROI)-based Unequal Loss Protection (ULP) scheme with no delay is proposed for High Definition (HD) interactive video applications such as video calls. The proposed scheme uses Data Partitioning and Flexible Macro block Ordering (FMO) tools of H.264/AVC and reduces error propagation. The obtained data demonstrates that this scheme achieves better ROI quality than others in high Packet Loss Rates (PLR). Second, it is also shown that the efficient scheme for protecting ROI-based interactive video applications in wide PLR ranges is switching both the Forward Error Correction (FEC) distribution pattern and the codec configuration between various scenarios depending on network conditions. This is shown by using both PSNR and SSIM metrics for quality measurement.