Ring-opening metathesis polymers for biodetection and signal amplification: Synthesis and self-assembly

N. B. Sankaran, Andrzej Z. Rys, Rachel Nassif, Manoj K. Nayak, Kimberly Metera, Bingzhi Chen, Hassan S. Bazzi, Hanadi F. Sleiman

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The ring-opening metathesis polymerization (ROMP) was used to develop a new class of block copolymers toward biological detection with signal amplification. For this, three classes of ROMP monomers were synthesized: (i) luminescent and electrochemiluminescent transition-metal-containing monomers, with ruthenium, osmium, and iridium bipyridine units, (ii) biologically compatible monomers and macromonomers containing oligothylene glycol units, and (iii) bioconjugatable monomers as well as monomers containing the biorecognition unit biotin. ROMP was used to efficiently combine these monomers into amphiphilic di-and triblock copolymers. Self-assembly of these block copolymers in aqueous media generates micellar spherical assemblies, which containa large number of luminescent transition-metal centers in their core, a biocompatible and biologically inert protecting shell, and biological recognition units or bioconjugatable groups on their periphery. These micelles can act as luminescent markers for biological molecules with potential for signal amplification. In addition, the monomers and polymers reported here can serve as useful biologically enabled building blocks for a number of applications, including drug delivery and tissue engineering.

Original languageEnglish
Pages (from-to)5530-5537
Number of pages8
JournalMacromolecules
Volume43
Issue number13
DOIs
Publication statusPublished - 13 Jul 2010

Fingerprint

Self assembly
Amplification
Polymers
Monomers
Ring opening polymerization
Block copolymers
Transition metals
Osmium
Iridium
Glycols
Ruthenium
Micelles
Biotin
Drug delivery
Tissue engineering
Molecules

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry

Cite this

Sankaran, N. B., Rys, A. Z., Nassif, R., Nayak, M. K., Metera, K., Chen, B., ... Sleiman, H. F. (2010). Ring-opening metathesis polymers for biodetection and signal amplification: Synthesis and self-assembly. Macromolecules, 43(13), 5530-5537. https://doi.org/10.1021/ma100234j

Ring-opening metathesis polymers for biodetection and signal amplification : Synthesis and self-assembly. / Sankaran, N. B.; Rys, Andrzej Z.; Nassif, Rachel; Nayak, Manoj K.; Metera, Kimberly; Chen, Bingzhi; Bazzi, Hassan S.; Sleiman, Hanadi F.

In: Macromolecules, Vol. 43, No. 13, 13.07.2010, p. 5530-5537.

Research output: Contribution to journalArticle

Sankaran, NB, Rys, AZ, Nassif, R, Nayak, MK, Metera, K, Chen, B, Bazzi, HS & Sleiman, HF 2010, 'Ring-opening metathesis polymers for biodetection and signal amplification: Synthesis and self-assembly', Macromolecules, vol. 43, no. 13, pp. 5530-5537. https://doi.org/10.1021/ma100234j
Sankaran, N. B. ; Rys, Andrzej Z. ; Nassif, Rachel ; Nayak, Manoj K. ; Metera, Kimberly ; Chen, Bingzhi ; Bazzi, Hassan S. ; Sleiman, Hanadi F. / Ring-opening metathesis polymers for biodetection and signal amplification : Synthesis and self-assembly. In: Macromolecules. 2010 ; Vol. 43, No. 13. pp. 5530-5537.
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