Retinal Tissue Thickness is Reduced in Diabetic Peripheral Neuropathy

Sangeetha Srinivasan, Nicola Pritchard, Dimitrios Vagenas, Katie Edwards, Geoff P. Sampson, Anthony W. Russell, Rayaz Malik, Nathan Efron

Research output: Contribution to journalArticle

10 Citations (Scopus)


Aim: To investigate the relationship between diabetic peripheral neuropathy (DPN) and retinal tissue thickness. Methods: Full retinal thickness in the central retinal, parafoveal, and perifoveal zones and thickness of the ganglion cell complex and retinal nerve fiber layer (RNFL) were assessed in 193 individuals (84 with type 1 diabetes, 67 with type 2 diabetes, and 42 healthy controls) using spectral domain optical coherence tomography. Among those with diabetes, 44 had neuropathy defined using a modified neuropathy disability score recorded on a 0–10 scale. Multiple regression analysis was performed to investigate the relationship between diabetic neuropathy and retinal tissue thickness, adjusted for the presence of diabetic retinopathy (DR), age, sex, duration of diabetes, and HbA1c levels. Results: In individuals with diabetes, perifoveal thickness was inversely related to the severity of neuropathy (p < 0.05), when adjusted for age, sex, duration of diabetes, and HbA1c levels. DR was associated with reduced thickness in parafovea (p < 0.01). The RNFL was thinner in individuals with greater degrees of neuropathy (p < 0.04). Conclusions: DPN is associated with structural compromise involving several retinal layers. This compromise may represent a threat to visual integrity and therefore warrants examination of functional correlates.

Original languageEnglish
Pages (from-to)1359-1366
Number of pages8
JournalCurrent Eye Research
Issue number10
Publication statusPublished - 2 Oct 2016
Externally publishedYes



  • Diabetic peripheral neuropathy
  • ganglion cell complex
  • neuropathy disability score
  • retinal nerve fiber layer
  • retinal thickness

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Srinivasan, S., Pritchard, N., Vagenas, D., Edwards, K., Sampson, G. P., Russell, A. W., Malik, R., & Efron, N. (2016). Retinal Tissue Thickness is Reduced in Diabetic Peripheral Neuropathy. Current Eye Research, 41(10), 1359-1366.