Retinal tissue thickness in type 1 and type 2 diabetes

Sangeetha Srinivasan, Nicola Pritchard, Geoff P. Sampson, Katie Edwards, Dimitrios Vagenas, Anthony W. Russell, Rayaz Malik, Nathan Efron

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The objective was to investigate full retinal and inner retinal thickness in individuals with type 1 and type 2 diabetes. Methods: Eighty-four individuals with type 1 diabetes (T1DM), 67 individuals with type 2 diabetes (T2DM) and 42 non-diabetic individuals (control group) were enrolled. Participants underwent full retinal thickness evaluation in the central retinal, parafoveal and perifoveal zones and in the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC), using spectral domain optical coherence tomography. As a preliminary step, the key variables of interest - age, sex, diabetic retinopathy (DR), duration of diabetes and HbA1c levels - were analysed and compared between the three groups. Full retinal thickness, RNFL and GCC thicknesses were also compared between the groups. The relationship between the type of diabetes and retinal tissue thickness was explored, adjusting for the five potential confounders. Results: Compared to individuals with T1DM, individuals with T2DM had significantly reduced full retinal thickness in the parafovea and perifovea and reduced RNFL and GCC thickness. The mean differences were six (p=0.020), seven (p=0.008), six (p=0.021) and four micrometres (p=0.013) for the parafovea, perifovea, RNFL and GCC thicknesses, respectively. Thicknesses within the central zone (p=0.018) and at the parafovea (p=0.007) were significantly reduced in T2DM when compared to the control group. After adjusting for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels, the relationship between type of diabetes and retinal tissue thickness was not statistically significant (p>0.056). Conclusion: Retinal tissue thickness is not significantly different between type 1 and type 2 diabetes, when adjusted for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalClinical and Experimental Optometry
Volume99
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016

Fingerprint

Type 1 Diabetes Mellitus
Nerve Fibers
Ganglia
Type 2 Diabetes Mellitus
Diabetic Retinopathy
Control Groups
Optical Coherence Tomography

Keywords

  • Diabetic retinopathy
  • Ganglion cell complex
  • Retinal nerve fibre layer
  • Retinal thickness
  • Type 1 diabetes
  • Type 2 diabetes

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry

Cite this

Srinivasan, S., Pritchard, N., Sampson, G. P., Edwards, K., Vagenas, D., Russell, A. W., ... Efron, N. (2016). Retinal tissue thickness in type 1 and type 2 diabetes. Clinical and Experimental Optometry, 99(1), 78-83. https://doi.org/10.1111/cxo.12318

Retinal tissue thickness in type 1 and type 2 diabetes. / Srinivasan, Sangeetha; Pritchard, Nicola; Sampson, Geoff P.; Edwards, Katie; Vagenas, Dimitrios; Russell, Anthony W.; Malik, Rayaz; Efron, Nathan.

In: Clinical and Experimental Optometry, Vol. 99, No. 1, 01.01.2016, p. 78-83.

Research output: Contribution to journalArticle

Srinivasan, S, Pritchard, N, Sampson, GP, Edwards, K, Vagenas, D, Russell, AW, Malik, R & Efron, N 2016, 'Retinal tissue thickness in type 1 and type 2 diabetes', Clinical and Experimental Optometry, vol. 99, no. 1, pp. 78-83. https://doi.org/10.1111/cxo.12318
Srinivasan S, Pritchard N, Sampson GP, Edwards K, Vagenas D, Russell AW et al. Retinal tissue thickness in type 1 and type 2 diabetes. Clinical and Experimental Optometry. 2016 Jan 1;99(1):78-83. https://doi.org/10.1111/cxo.12318
Srinivasan, Sangeetha ; Pritchard, Nicola ; Sampson, Geoff P. ; Edwards, Katie ; Vagenas, Dimitrios ; Russell, Anthony W. ; Malik, Rayaz ; Efron, Nathan. / Retinal tissue thickness in type 1 and type 2 diabetes. In: Clinical and Experimental Optometry. 2016 ; Vol. 99, No. 1. pp. 78-83.
@article{48e591bd215a4e508dad4e282a3b3a77,
title = "Retinal tissue thickness in type 1 and type 2 diabetes",
abstract = "Background: The objective was to investigate full retinal and inner retinal thickness in individuals with type 1 and type 2 diabetes. Methods: Eighty-four individuals with type 1 diabetes (T1DM), 67 individuals with type 2 diabetes (T2DM) and 42 non-diabetic individuals (control group) were enrolled. Participants underwent full retinal thickness evaluation in the central retinal, parafoveal and perifoveal zones and in the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC), using spectral domain optical coherence tomography. As a preliminary step, the key variables of interest - age, sex, diabetic retinopathy (DR), duration of diabetes and HbA1c levels - were analysed and compared between the three groups. Full retinal thickness, RNFL and GCC thicknesses were also compared between the groups. The relationship between the type of diabetes and retinal tissue thickness was explored, adjusting for the five potential confounders. Results: Compared to individuals with T1DM, individuals with T2DM had significantly reduced full retinal thickness in the parafovea and perifovea and reduced RNFL and GCC thickness. The mean differences were six (p=0.020), seven (p=0.008), six (p=0.021) and four micrometres (p=0.013) for the parafovea, perifovea, RNFL and GCC thicknesses, respectively. Thicknesses within the central zone (p=0.018) and at the parafovea (p=0.007) were significantly reduced in T2DM when compared to the control group. After adjusting for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels, the relationship between type of diabetes and retinal tissue thickness was not statistically significant (p>0.056). Conclusion: Retinal tissue thickness is not significantly different between type 1 and type 2 diabetes, when adjusted for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels.",
keywords = "Diabetic retinopathy, Ganglion cell complex, Retinal nerve fibre layer, Retinal thickness, Type 1 diabetes, Type 2 diabetes",
author = "Sangeetha Srinivasan and Nicola Pritchard and Sampson, {Geoff P.} and Katie Edwards and Dimitrios Vagenas and Russell, {Anthony W.} and Rayaz Malik and Nathan Efron",
year = "2016",
month = "1",
day = "1",
doi = "10.1111/cxo.12318",
language = "English",
volume = "99",
pages = "78--83",
journal = "Clinical and Experimental Optometry",
issn = "0816-4622",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Retinal tissue thickness in type 1 and type 2 diabetes

AU - Srinivasan, Sangeetha

AU - Pritchard, Nicola

AU - Sampson, Geoff P.

AU - Edwards, Katie

AU - Vagenas, Dimitrios

AU - Russell, Anthony W.

AU - Malik, Rayaz

AU - Efron, Nathan

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: The objective was to investigate full retinal and inner retinal thickness in individuals with type 1 and type 2 diabetes. Methods: Eighty-four individuals with type 1 diabetes (T1DM), 67 individuals with type 2 diabetes (T2DM) and 42 non-diabetic individuals (control group) were enrolled. Participants underwent full retinal thickness evaluation in the central retinal, parafoveal and perifoveal zones and in the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC), using spectral domain optical coherence tomography. As a preliminary step, the key variables of interest - age, sex, diabetic retinopathy (DR), duration of diabetes and HbA1c levels - were analysed and compared between the three groups. Full retinal thickness, RNFL and GCC thicknesses were also compared between the groups. The relationship between the type of diabetes and retinal tissue thickness was explored, adjusting for the five potential confounders. Results: Compared to individuals with T1DM, individuals with T2DM had significantly reduced full retinal thickness in the parafovea and perifovea and reduced RNFL and GCC thickness. The mean differences were six (p=0.020), seven (p=0.008), six (p=0.021) and four micrometres (p=0.013) for the parafovea, perifovea, RNFL and GCC thicknesses, respectively. Thicknesses within the central zone (p=0.018) and at the parafovea (p=0.007) were significantly reduced in T2DM when compared to the control group. After adjusting for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels, the relationship between type of diabetes and retinal tissue thickness was not statistically significant (p>0.056). Conclusion: Retinal tissue thickness is not significantly different between type 1 and type 2 diabetes, when adjusted for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels.

AB - Background: The objective was to investigate full retinal and inner retinal thickness in individuals with type 1 and type 2 diabetes. Methods: Eighty-four individuals with type 1 diabetes (T1DM), 67 individuals with type 2 diabetes (T2DM) and 42 non-diabetic individuals (control group) were enrolled. Participants underwent full retinal thickness evaluation in the central retinal, parafoveal and perifoveal zones and in the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC), using spectral domain optical coherence tomography. As a preliminary step, the key variables of interest - age, sex, diabetic retinopathy (DR), duration of diabetes and HbA1c levels - were analysed and compared between the three groups. Full retinal thickness, RNFL and GCC thicknesses were also compared between the groups. The relationship between the type of diabetes and retinal tissue thickness was explored, adjusting for the five potential confounders. Results: Compared to individuals with T1DM, individuals with T2DM had significantly reduced full retinal thickness in the parafovea and perifovea and reduced RNFL and GCC thickness. The mean differences were six (p=0.020), seven (p=0.008), six (p=0.021) and four micrometres (p=0.013) for the parafovea, perifovea, RNFL and GCC thicknesses, respectively. Thicknesses within the central zone (p=0.018) and at the parafovea (p=0.007) were significantly reduced in T2DM when compared to the control group. After adjusting for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels, the relationship between type of diabetes and retinal tissue thickness was not statistically significant (p>0.056). Conclusion: Retinal tissue thickness is not significantly different between type 1 and type 2 diabetes, when adjusted for age, sex, diabetic retinopathy, duration of diabetes and HbA1c levels.

KW - Diabetic retinopathy

KW - Ganglion cell complex

KW - Retinal nerve fibre layer

KW - Retinal thickness

KW - Type 1 diabetes

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=84957991460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957991460&partnerID=8YFLogxK

U2 - 10.1111/cxo.12318

DO - 10.1111/cxo.12318

M3 - Article

C2 - 26875856

AN - SCOPUS:84957991460

VL - 99

SP - 78

EP - 83

JO - Clinical and Experimental Optometry

JF - Clinical and Experimental Optometry

SN - 0816-4622

IS - 1

ER -