Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1

Robert J. Hogan, Guangping Gao, Thomas Rowe, Peter Bell, Douglas Flieder, Jason Paragas, Gary P. Kobinger, Nelson A. Wivel, Ronald G. Crystal, Julie Boyer, Heinz Feldmann, Thomas G. Voss, James M. Wilson

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the tangs and the development of self-limited broachiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus an lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.

Original languageEnglish
Pages (from-to)11416-11421
Number of pages6
JournalJournal of Virology
Volume78
Issue number20
DOIs
Publication statusPublished - 1 Oct 2004

    Fingerprint

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Hogan, R. J., Gao, G., Rowe, T., Bell, P., Flieder, D., Paragas, J., Kobinger, G. P., Wivel, N. A., Crystal, R. G., Boyer, J., Feldmann, H., Voss, T. G., & Wilson, J. M. (2004). Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1. Journal of Virology, 78(20), 11416-11421. https://doi.org/10.1128/JVI.78.20.11416-11421.2004