Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1

Robert J. Hogan, Guangping Gao, Thomas Rowe, Peter Bell, Douglas Flieder, Jason Paragas, Gary P. Kobinger, Nelson A. Wivel, Ronald Crystal, Julie Boyer, Heinz Feldmann, Thomas G. Voss, James M. Wilson

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the tangs and the development of self-limited broachiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus an lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.

Original languageEnglish
Pages (from-to)11416-11421
Number of pages6
JournalJournal of Virology
Volume78
Issue number20
DOIs
Publication statusPublished - 1 Oct 2004
Externally publishedYes

Fingerprint

Coronavirus Infections
Severe Acute Respiratory Syndrome
Coronavirus
Coronavirinae
Inhalation
breathing
Viruses
viruses
interferons
Virus Replication
virus replication
infection
respiratory tract diseases
Interferons
Lung Diseases
spleen
epithelial cells
Spleen
inflammation
Epithelial Cells

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Hogan, R. J., Gao, G., Rowe, T., Bell, P., Flieder, D., Paragas, J., ... Wilson, J. M. (2004). Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1. Journal of Virology, 78(20), 11416-11421. https://doi.org/10.1128/JVI.78.20.11416-11421.2004

Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1. / Hogan, Robert J.; Gao, Guangping; Rowe, Thomas; Bell, Peter; Flieder, Douglas; Paragas, Jason; Kobinger, Gary P.; Wivel, Nelson A.; Crystal, Ronald; Boyer, Julie; Feldmann, Heinz; Voss, Thomas G.; Wilson, James M.

In: Journal of Virology, Vol. 78, No. 20, 01.10.2004, p. 11416-11421.

Research output: Contribution to journalArticle

Hogan, RJ, Gao, G, Rowe, T, Bell, P, Flieder, D, Paragas, J, Kobinger, GP, Wivel, NA, Crystal, R, Boyer, J, Feldmann, H, Voss, TG & Wilson, JM 2004, 'Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1', Journal of Virology, vol. 78, no. 20, pp. 11416-11421. https://doi.org/10.1128/JVI.78.20.11416-11421.2004
Hogan, Robert J. ; Gao, Guangping ; Rowe, Thomas ; Bell, Peter ; Flieder, Douglas ; Paragas, Jason ; Kobinger, Gary P. ; Wivel, Nelson A. ; Crystal, Ronald ; Boyer, Julie ; Feldmann, Heinz ; Voss, Thomas G. ; Wilson, James M. / Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1. In: Journal of Virology. 2004 ; Vol. 78, No. 20. pp. 11416-11421.
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