Research opportunities and advances in lung disease

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Lung diseases cause morbidity, mortality, and economic burden. Susceptibility to pathogenesis of most lung diseases result from a complex interaction of a relevant challenge from the environment, genetic background, and the nature of the host responses. Cutting-edge research in lung disease now centers on understanding the lung as a genetically determined biological organ that functions to mediate gas exchange and defend against a hostile environment. A major challenge is to determine the hierarchy of gene expression that integrates the function of multiple cell types in this complex anatomy. Emerging therapies that will play a major role in the future treatment of lung disease include the use of recombinant proteins, including monoclonal antibodies, cell therapy (including stem cells), and gene therapy. Future advances will include the cure of the major hereditary lung disorders by gene therapy, new treatment for asthma, chronic obstructive pulmonary disease, and interstitial lung disease; development of vaccines to protect the lung from major lung pathogens; and pathogen-specific "designer" therapies to eradicate chronic lung infections.

Original languageEnglish
Pages (from-to)612-618
Number of pages7
JournalJournal of the American Medical Association
Volume285
Issue number5
Publication statusPublished - 7 Feb 2001
Externally publishedYes

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Lung Diseases
Lung
Research
Cell- and Tissue-Based Therapy
Genetic Therapy
Play Therapy
Interstitial Lung Diseases
Recombinant Proteins
Chronic Obstructive Pulmonary Disease
Anatomy
Stem Cells
Therapeutics
Vaccines
Asthma
Gases
Monoclonal Antibodies
Economics
Morbidity
Gene Expression
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Research opportunities and advances in lung disease. / Crystal, Ronald.

In: Journal of the American Medical Association, Vol. 285, No. 5, 07.02.2001, p. 612-618.

Research output: Contribution to journalArticle

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