Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy

Marketa Hecht, Ling Lin, Clete A. Kushida, Dale T. Umetsu, Shahrad Taheri, Mali Einen, Emmanuel Mignot

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Objective: To explore whether acute destruction of hypocretin cells in a patient with narcolepsy could be detected and if the course of the disease could be reversed or altered by the use of prednisone for immunosuppression. Design: Case report. Setting: A sleep-clinic population in a tertiary-care hospital Patient: An 8-year-old boy with a very acute recent (< 2 month) onset of sleepiness. Methods: Sleep studies; fluid-attenuated inversion recovery and gadolinium magnetic resonance imaging studies with a focus on the hypothalamus; examinations of cerebrospinal fluid for cytology, protein, and hypocretin-1 levels; and HLA typing were performed. Intervention: A 3-week regimen of 1 mg kg-1-day-1 of prednisone was administered in an attempt to modify the course of the disease. Results and Conclusion: Sleep evaluations were consistent with a diagnosis of narcolepsy. Hypocretin-1 was absent in the cerebrospinal fluid, and HLA-DQB1*0602 was present. All other results were within normal limits, and prednisone did not have any noticeable effects. Clinical manifestation of narcolepsy might occur when the hypocretin cell damage is too advanced to be reversible.

Original languageEnglish
Pages (from-to)809-810
Number of pages2
JournalSleep
Volume26
Issue number7
Publication statusPublished - 1 Nov 2003
Externally publishedYes

Fingerprint

Narcolepsy
Prednisone
Immunosuppression
Sleep
Cerebrospinal Fluid Proteins
Histocompatibility Testing
Gadolinium
Tertiary Healthcare
Tertiary Care Centers
Hypothalamus
Cell Biology
Cerebrospinal Fluid
Magnetic Resonance Imaging
Orexins
Population

ASJC Scopus subject areas

  • Physiology

Cite this

Hecht, M., Lin, L., Kushida, C. A., Umetsu, D. T., Taheri, S., Einen, M., & Mignot, E. (2003). Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy. Sleep, 26(7), 809-810.

Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy. / Hecht, Marketa; Lin, Ling; Kushida, Clete A.; Umetsu, Dale T.; Taheri, Shahrad; Einen, Mali; Mignot, Emmanuel.

In: Sleep, Vol. 26, No. 7, 01.11.2003, p. 809-810.

Research output: Contribution to journalArticle

Hecht, M, Lin, L, Kushida, CA, Umetsu, DT, Taheri, S, Einen, M & Mignot, E 2003, 'Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy', Sleep, vol. 26, no. 7, pp. 809-810.
Hecht, Marketa ; Lin, Ling ; Kushida, Clete A. ; Umetsu, Dale T. ; Taheri, Shahrad ; Einen, Mali ; Mignot, Emmanuel. / Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy. In: Sleep. 2003 ; Vol. 26, No. 7. pp. 809-810.
@article{79a6d83afba348cd9d6550ac8d20056d,
title = "Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy",
abstract = "Objective: To explore whether acute destruction of hypocretin cells in a patient with narcolepsy could be detected and if the course of the disease could be reversed or altered by the use of prednisone for immunosuppression. Design: Case report. Setting: A sleep-clinic population in a tertiary-care hospital Patient: An 8-year-old boy with a very acute recent (< 2 month) onset of sleepiness. Methods: Sleep studies; fluid-attenuated inversion recovery and gadolinium magnetic resonance imaging studies with a focus on the hypothalamus; examinations of cerebrospinal fluid for cytology, protein, and hypocretin-1 levels; and HLA typing were performed. Intervention: A 3-week regimen of 1 mg kg-1-day-1 of prednisone was administered in an attempt to modify the course of the disease. Results and Conclusion: Sleep evaluations were consistent with a diagnosis of narcolepsy. Hypocretin-1 was absent in the cerebrospinal fluid, and HLA-DQB1*0602 was present. All other results were within normal limits, and prednisone did not have any noticeable effects. Clinical manifestation of narcolepsy might occur when the hypocretin cell damage is too advanced to be reversible.",
author = "Marketa Hecht and Ling Lin and Kushida, {Clete A.} and Umetsu, {Dale T.} and Shahrad Taheri and Mali Einen and Emmanuel Mignot",
year = "2003",
month = "11",
day = "1",
language = "English",
volume = "26",
pages = "809--810",
journal = "Sleep",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "7",

}

TY - JOUR

T1 - Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy

AU - Hecht, Marketa

AU - Lin, Ling

AU - Kushida, Clete A.

AU - Umetsu, Dale T.

AU - Taheri, Shahrad

AU - Einen, Mali

AU - Mignot, Emmanuel

PY - 2003/11/1

Y1 - 2003/11/1

N2 - Objective: To explore whether acute destruction of hypocretin cells in a patient with narcolepsy could be detected and if the course of the disease could be reversed or altered by the use of prednisone for immunosuppression. Design: Case report. Setting: A sleep-clinic population in a tertiary-care hospital Patient: An 8-year-old boy with a very acute recent (< 2 month) onset of sleepiness. Methods: Sleep studies; fluid-attenuated inversion recovery and gadolinium magnetic resonance imaging studies with a focus on the hypothalamus; examinations of cerebrospinal fluid for cytology, protein, and hypocretin-1 levels; and HLA typing were performed. Intervention: A 3-week regimen of 1 mg kg-1-day-1 of prednisone was administered in an attempt to modify the course of the disease. Results and Conclusion: Sleep evaluations were consistent with a diagnosis of narcolepsy. Hypocretin-1 was absent in the cerebrospinal fluid, and HLA-DQB1*0602 was present. All other results were within normal limits, and prednisone did not have any noticeable effects. Clinical manifestation of narcolepsy might occur when the hypocretin cell damage is too advanced to be reversible.

AB - Objective: To explore whether acute destruction of hypocretin cells in a patient with narcolepsy could be detected and if the course of the disease could be reversed or altered by the use of prednisone for immunosuppression. Design: Case report. Setting: A sleep-clinic population in a tertiary-care hospital Patient: An 8-year-old boy with a very acute recent (< 2 month) onset of sleepiness. Methods: Sleep studies; fluid-attenuated inversion recovery and gadolinium magnetic resonance imaging studies with a focus on the hypothalamus; examinations of cerebrospinal fluid for cytology, protein, and hypocretin-1 levels; and HLA typing were performed. Intervention: A 3-week regimen of 1 mg kg-1-day-1 of prednisone was administered in an attempt to modify the course of the disease. Results and Conclusion: Sleep evaluations were consistent with a diagnosis of narcolepsy. Hypocretin-1 was absent in the cerebrospinal fluid, and HLA-DQB1*0602 was present. All other results were within normal limits, and prednisone did not have any noticeable effects. Clinical manifestation of narcolepsy might occur when the hypocretin cell damage is too advanced to be reversible.

UR - http://www.scopus.com/inward/record.url?scp=0347120596&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347120596&partnerID=8YFLogxK

M3 - Article

C2 - 14655912

AN - SCOPUS:0347120596

VL - 26

SP - 809

EP - 810

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - 7

ER -